Nanoparticle Systems Engineering
Welcome to the Nanoparticle Systems Engineering group based at Empa and ETH Zurich. We design particle-enabled approaches to address clinical needs in disease etiology, diagnostics and drug delivery.
Our activities are centered around
- a better understanding of disease etiology by employing particle-based model systems (Disease Etiology),
- the development of particle-based biosensors (Diagnostics), and
the design of particles for targeted drug delivery (Drug Delivery).
The design specs for our particle-based solutions are given by the clinical problem to be solved. We design our particle-based solutions bottom up in close exchange with our clinical collaborators as well as academic partner institutions around the world. We have expertise in particle synthesis and functionalization, characterization and imaging of particle-based systems, as well as translational nanomedicine.
We acknowledge financial support from the Swiss National Science Foundation, the Personalized Health and Related Technologies (PHRT) Initiative of the ETH Domain, the Swiss Heart Foundation, Krebsliga, the Novartis Foundation for Biomedical Research, the Novartis FreeNovation Program, the Bangerter Rhyner Foundation, the Helmut Horten Foundation, the Olga Mayenfisch Foundation, the OPO Foundation and others.
Theranostic Magnetic Blood Purification
We develop a theranostic nanoparticle-based approach that allows capturing of pathogenic compounds from blood and rapid identification of the pathogen enabling doctors to then start appropriate treatment in due time.
We have close collaborations with Marco Lattuada (AMI/University of Fribourg) and Gerald Pier (Harvard University). This project is supported by the Novartis Foundation for medical-biological research.
Tissue Glue for Integrative Wound Care and Regenerative Medicine (NANOGLUE)
We engineer fully resorbable bioactive nanoparticle-based tissue glues that allow surgeons to achieve rapid hemostasis and wound closing and optimally support the natural healing process by releasing bioactive compounds.
This work is collaboration with the Cantonal Hospital (Oncology Department) and the Inselspital Bern (Plastic Surgery Department). We acknowledge support from the Swiss National Science Foundation, the Bangerter Rhyner Foundation, the Helmut Horten Foundation and the OPO Foundation!
We employ a combinatorial materials science approach that enables us for the first time to integrate structural information of the mineral with biochemical information. In this way, we achieve a fresh view on complex biomineralization mechanisms involved in pathological calcification and gain new insights into the underlying processes that can then be leveraged to develop novel curative strategies.
These activities are kindly supported by the Swiss Heart Foundation, the Swiss National Science Foundation and the ETH Domain SFA Personalized Health and Related Technologies (PHRT) Program and are carried out in close collaboration with the Mineralomics group chaired by Dr. S. Bertazzo, University College London, UK, the Cantonal Hospital St. Gallen KSSG (Prof. Thürlimann / PD Dr. Knauer, Prof. Hornung and Prof. Wildermuth), and the ARTORG/Inselspital Bern (Prof. Obrist and Prof. Carrel).
Multiscale Correlative BioImaging (eLUM)
We develop methods that allow us to integrate the major imaging methods used in biology, from the micro to the macro scale. With this approach we are able to correlate data from the key imaging methods used by today’s biologists and biochemists thereby providing groundwork to significantly advance the holistic understanding of both physiological and pathological processes by linking structural with functional information. Our activities include Correlative Cathodoluminescence Electron Microscopy (CCLEM), molecular labelling approaches and chemometric analyses of tissues by vibrational spectroscopy approaches.
We acknowledge support from the European Union Seventh Framework Programm ESTEEM2 (imaging), the Novartis Freenovation Program (AI-assisted Spectral Pathology) the Olga Mayenfisch Foundation (Molecular Radiotherapy).
Particle Characterization Lab & Measurement Science
We host a particle characterization lab where we investigate colloidal stability of inorganic (metal and metal oxides) and organic particles (liposomes, polymersomes and exosomes) under a range of physiologically relevant conditions. We are part of the European Nanoparticle Characterization Lab project (EU-NCL). In addition to characterizing colloidal suspensions, we develop tools for online monitoring of reactions on particle surfaces. Our particle characterization instruments (including a Nanoparticle Tracking Analysis Instrument with Fluorescence module and a Malvern Zeta sizer) are accessible to other users within and outside of Empa.
Prof. Dr Inge K. Herrmann, Assistant Professor (ETH, D-MAVT) and Group Leader
Alma Mater: ETH Zurich
Keywords: Chemical Engineering, Particle Synthesis and Functionalization, Bioimaging, Translational Research
Dr Matthias Rösslein, Senior Scientist
Alma Mater: University of Basel
Keywords: Physical Chemistry, Particle Characterization, Measurement Science, Bioinformatics, Next Generation Sequencing
Dr Alexander Gogos, Research Specialist
Alma Mater: ETH Zurich, RWTH Aachen
Keywords: Analytical Chemistry, Elemental Analysis (ICP-OES/MS), Field-Flow-Fractionation, Analytical Electron Microscopy
Dr Fabian Starsich, Postdoctoral Reserach Associate
Alma Mater: ETH Zurich
Keywords: Nanoparticle Synthesis, Engineering, Biomedical Applications
Dr Elena Tsolaki, Postdoctoral Research Associate at Empa/ETHZ
Alma Mater: University College London
Keywords: Mineralomics, Microscopy, Calcification
Dr Alice Balfourier, Postdoctoral Research Associate at Empa/ETHZ
Alma Mater: University of Paris
Keywords: Advanced Microcopy, Biotransformation, Inorganic Nanomaterials, Omics
Dr Thomas Rduch, MD, Clinical Research Fellow
Clinical Research Fellow and Attending Physician at KSSG
Dr Tino Matter, ETH Pioneer Fellow (Anavo)
Alma Mater: University of Basel (MSc), ETH Zurich (PhD)
Key words: Nanotechnology, Physics, Programming
Dr Alexandre Anthis, ETH Pioneer Fellow (Veltist)
Alma Mater: University of Geneva (MSc), ETH Zurich (PhD)
Key words: (Polymer) Chemistry, ATRP, Analytics, Entrepreneurship
Mr. Lukas Gerken, PhD student since 04/2018
Alma Mater: University of Cologne and TU Vienna
Key words: Physics, Nanoparticle Synthesis, Optical Properties of Nanomaterials
Mr. Subas Scheibler, PhD student (jointly with 203) since 04/2019
Alma Mater: University of Zurich
Key words: Physics, Thin Film Fab, New Materials for Healthcare
Ms. Anna L. Neuer, PhD student since 05/2019
Alma Mater: University of Constance, D
Keywords: Cell Culture, Metal Organic Frameworks, Microscopy
Mr. Oscar Cipolato, PhD student since 10/20
Alma Mater: Msc Physics (University of Padova)
Keywords: Physics, Simulations, Coding
Ms. Judith Ng, PhD student since 10/20
Alma Mater: Msc Biomedical Engineering (University of Toronto)
Keywords: Cell culture, Bacteria culture, Tissue engineering, Adhesion
Ms. Monika Zimmermann, PhD student since 02/21
MSc Physics (ETHZ)
Keywords: Physics, Simulations, Radiotherapy, Nanoparticles
Mr. Erik Mayr, PhD Student since 05/21
MSc Physiscs (University of Basel)
Keywords: Magnetism, Nanoparticles, Sputtering, Thin Film Phyiscis
Mr. Benjamin Suter, PhD student since 07/21
MSc Physics (ETHZ)
Keywords: AI, Computer Vision, Sensing
Dr Jian Hao-Li, Postdoctoral Reserach Associate, Novartis FreeNovation
Alma Mater: University of Cambridge, UK
Keywords: Theoretical Physics, Condensed Matter Physics, Quantum Mechanics, Deep Learning, Machine Learning, Data Analysis
Dr Kerda Keevend, Postdoctoral Research Associate at ETH Zurich (D-MAVT)
Alma Mater: ETH Zurich
Keywords: Inorganic Nanocrystal Synthesis, Correlative Cathodoluminescence Electron Microscopy
Dr Kerda Keevend, PhD student 04/2016 - 12/2019 (defended 7/11/19)
Dr Tino Matter, PhD student, 05/2017-09/2020 (defended 18/09/2020)
Dr Alexandre Anthis, PhD student, 10/2017-05/2021 (defended 06/05/2021)
BSc and MSc students
Mr. Alexander Jessernig, MSc student, D-ITET, MSc thesis, 2021
Ms. Maren Gerdes, BSc student, Karolinska, 2021
Mr. Juri Nowak, BSc student, ETHZ, D-MAVT, BSc thesis, 2020
Mr. Raphael Langenegger, ETHZ, D-MAVT, BSc thesis, 2020
Mr. Jerome Schlatter, ETHZ, D-MAVT, BSc thesis, 2020
Mr. Eric Rüttimann, MSc student Chemistry, ETHZ, MSc thesis, 2020
Ms. Leonida Maliqi, MSc student, 2019, University of Geneva
Ms. Lea Pompizzi, MSc student Chemistry, 2019, ETH Zurich
Mr. Xueqian Hu, MSc student, 2019, MSc student, University of Darmstadt, Germany
Ms. Meagan Doppegieter 2018-2019, MSc student, University of Amsterdam (UvA), NL
Mr. Henry Korhonen, 2018, ETH Zurich, D-MATL, BSc student
Ms. Apolline Anthis, 2018, University of Ioannina (GR), MSc student
Ms. Lea Furer, 2018, ETH Zurich, D-ITET, MSc student
Mr. Roman Krummenacher, 2018, ETH Zurich, D-MAVT, BSc student
Ms. Egle Truska, 2017-2018, University of Tallinn (E), MSc student
Mr. Dimitri Hürlimann, 2017-2018, University of Basel, MSc student
Mrs. Behnaz Ghaemi, 2017, University of Tehran, Visiting PhD student
Mr. Louis Didierlaurent, 2016-2017, Ecole Superieure de Chimie Physique Electronique de Lyon, MSc student
Mr. Nino Demarmels, 2016-2017, ETH Zurich, MSc student
Mr. Samuel Staubli, 2016, ETH Zurich, Project student
Mr. Marco Galli, 2016, University of Milan, Visiting PhD student
Ms. Anna L. Neuer, 2016, University of Konstanz, BSc student
Mr. Eric Rüttimann, MSc student Chemistry
Matter, Martin T., Maliqi, Leonida, Keevend, Kerda, Guimond, Stefanie, Ng, Judith, Armagan, Efe, Rottmar, Markus and Inge Herrmann*.
One-Step Synthesis of Versatile Antimicrobial Nano-Architected Implant Coatings for Hard and Soft Tissue Healing. ACS Applied Materials & Interfaces 13.28 (2021): 33300-33310.
Herrmann, Inge K.*, Wood, Matthew J.A. and Gregor Fuhrmann.
Extracellular vesicles as a next-generation drug delivery platform. Nature Nanotechnology 16 (2021): 748-759.
Geissel Felix, Platania, Varvara, Gogos, Alexander, Herrmann, Inge, Belibasakis, Georgios, Chatzinikolaidou, Maria, Sotiriou, Georgios, Journal of Colloids and Interfaces, accepted, 2021.
Lese, Ioana, Tsai, Catherine, Matter, Martin T., Wüthrich, Tsering, Scheer, Helene S., Taddeo, Adriano, Constantinescu, Mihai A., Herrmann, Inge and Radu Olariu.
Mixed Metal Oxide Nanoparticle Formulations for the Treatment of Seroma. ACS Biomaterials Science & Engineering 7.6 (2021): 2676-2686.
Gerken, Lukas R.H., Neuer, Anna L., Gschwend, Pascal, Keevend, Kerda, Gogos, Alexander, Anthis, Alexandre H.C., Aengenheister, Leonie, Pratsinis, Sotiris E., Plasswilm, Ludwig and Inge Herrmann*.
Scalable Synthesis of Ultrasmall Metal Oxide Radio-Enhancers Outperforming Gold. Chemistry of Materials 33.9 (2021): 3098-3112.
Matter, Martin T., Doppegieter, Meagan, Gogos, Alexander, Keevend, Kerda, Ren, Qun and Inge Herrmann*.
Inorganic nanohybrids combat antibiotic-resistant bacteria hiding within human macrophages. Nanoscale 13.17 (2021): 8224-8234. **Emerging Investigator Collection
Anthis, Alexandre H. C., Hu, Xueqian, Matter, Martin T., Neuer, Anna L., Wei, Kongchang, Schlegel, Andrea A., Starsich, Fabian H. L. and Inge K. Herrmann*.
Chemically Stable, Strongly Adhesive Sealant Patch for Intestinal Anastomotic Leakage Prevention. Advanced Functional Materials (2021): 2007099.
Gschwend, Pascal, Keevend, Kerda, Aellen, Marianne, Gogos, Alexander, Krumeich, Frank, Herrmann, Inge K. and Sotiris E. Pratsinis.
Bi2O3 boosts brightness, biocompatibility and stability of Mn-doped Ba3(VO4)2 as NIR-II contrast agent. Journal of Materials Chemistry B (2021).
Gschwend, Pascal, Hintze, Justin M., Herrmann, Inge K., Pratsinis, Sotiris E. and Fabian H. L. Starsich.
Precision in Thermal Therapy: Clinical Requirements and Solutions from Nanotechnology. Advanced Therapeutics 4.2 (2021): 2000193.
K. Keevend, R. Krummenacher, E. Truska, L.H.R Gerken, A. Gogos, M. Stiefel, I.K. Herrmann*, Correlative Cathodoluminescence Electron Microscopy: Immunolabelling using Rare-Earth Element doped Nanoparticles, Small, accepted, 2020
M.T. Matter, S. Probst, S. Laeuchli, I.K. Herrmann*, Uniting Drug and Delivery: Metal Oxide Hybrid Nanotherapeutics for Skin Wound Care, Pharmaceutics, accepted (2020). Invited article - Special Issue on Hybrid Multifunctional Drug Delivery Systems
K. Keevend, T. Coenen, I.K. Herrmann*, Correlative Cathodoluminescence Electron Microscopy Bioimaging: towards Single Protein Labelling with Ultrastructural Context, Nanoscale (2020).
A.L. Neuer, L.H.R. Gerken, K. Keevend, A. Gogos, I.K. Herrmann*, Uptake, Distribution and Radio-enhancement Effects of Gold Nanoparticles in Tumor Microtissues, Nanoscale Adv. (2020).
M.T. Matter, J.H. Li, I. Lese, C. Schreiner, L. Bernard, O. Scholder, J. Hubeli, K. Keevend, E. Tsolaki, E. Bertero, S. Bertazzo, R. Zboray, R. Olariu, M. Constantinescu, R. Figi, I.K. Herrmann*, Multi-scale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and Biotransformation, Advanced Science, accepted (2020).
P.M. Gschwend, D. Niedbalka, L.R.H. Gerken, I.K. Herrmann, S.E. Pratsinis, Simultaneous Nanothermometry and Deep-tissue Imaging, Advanced Science, DOI: 10.1002/advs.202000370 (2020).
F. Iacoviello, E. Moeendarbary, A.C. Kirby, Y. Javanmardi, E. Tsolaki, M. Shabanli, A.C. Sharp, M.J. Hayes, K. Keevend, D.J. Brett, J.-H. Li, P.R. Shearing, A. Olivo, I.K. Herrmann, S.E. Evans, M. Moazen, S. Bertazzo, The multiscale hierarchical structure of heloderma suspectum osteoderms and their mechanical properties, Acta Biomaterialia, accepted, 2020.
E. Tsolaki, W. Doran, L. Magnani, A. Olivo, I.K. Herrmann, S. Bertazzo, Invasive breast tumors are characterized by the presence of crystalline nanoparticles, biorxiv, 2020.
E. Tsolaki, L. Didierlaurent, E. Müller, M. Rottmar, N. Latif, A.H. Chester, I.K. Herrmann, S. Bertazzo, Electron microscopy characterization of minerals formed in vitro by human bone cells and vascular smooth muscle cells, bioRXiv, https://doi.org/10.1101/661785.
K.C. Wei, B. Senturk, M.T. Matter, X. Wu, I.K. Herrmann, M. Rottmar, C. Toncelli, Mussel-inspired injectable hydrogel adhesive formed under mild conditions features near-native tissue properties, ACS Applied Materials and Interfaces, accepted.
A.H.C. Anthis, M.T. Matter, K. Keevend, L.H.R. Gerken, S. Scheibler, S. Doswald, A. Gogos, I.K. Herrmann*, Tailoring the Colloidal Stability, Magnetic Separability and Cytocompatibility of High-Capacity Magnetic Anion Exchangers, ACS Applied Materials and Interfaces, accepted, 2019.
A.H.C. Anthis, E. Tsolaki, L. Didierlaurent, S. Staubli, R. Zboray, A. Neels, D. Dietrich, P. Manser, L.M. Desbiolles, S. Leschka, S. Wildermuth, S. Lehner, P. Chavatte-Palmer, W. Jochum, P. Wick, A, Dommann, T. Bürki-Turnherr, T. Fischer, R. Hornung, S. Bertazzo, I.K. Herrmann*, Nano-analytical Characterization of Endogenous Minerals in Healthy Placental Tissue: Mineral Distribution, Composition and Ultrastructure, Analyst, 2019, 144, 6850-6857. * featured on the front cover
K. Keevend, L. Puust, K. Kurvits, L.H.R. Gerken, F.H.L Starsich, J.H. Li, M.T. Matter, A. Spyrogianni, G. Sotiriou, M. Stiefel, I.K. Herrmann*,
F.H.L. Starsich, I.K. Herrmann, S.E. Pratsinis, Nanoparticles for Biomedicine: Coagulation during Synthesis and Applications, Annual Review of Chemical and Biomolecular Engineering, accepted, 2019.
M.T. Matter, L. Furer, F.H.L. Starsich, G. Fortunato, S.E. Pratsinis, I.K. Herrmann*, Engineering the Bioactivity of Flame-made Ceria and Ceria/Bioglass Hybrid Nanoparticles, ACS Applied Materials and Interfaces, accepted, 2018. *senior and corresponding author
L. Gerken, K. Keevend, Y. Zhang, F.H.L. Starsich, C. Eberhardt, G. Panzarasa, M.T. Matter, A. Wichser, A. Boss, A. Neels, I.K. Herrmann*, Lanthanide-doped Hafnia Nanoparticles for Multimodal Theranostics, ACS Applied Materials and Interfaces, accepted, 2018. *senior and corresponding author
I. Lese, D.A. Graf, C. Tsai, A. Taddeo, M.T. Matter, M. Constantinescu, I.K. Herrmann, R. Olariu, Bioactive nanoparticle-based formulations increase survival area of perforator flaps in a rat model, Plos One, accepted, 2018.
F.H.L. Starsich, C. Eberhard, K. Keevend, A. Boss, A.M. Hirt, I.K. Herrmann, S.E. Pratsinis, Reduced magnetic coupling in ultra-small iron oxide T1 contrast agents, ACS Applied Bio Materials, accepted, 2018.
E. Bertero, M. Hasegawa, S. Staubli, E. Pellicer, I.K. Herrmann, J. Sort, J. Michler, L. Philippe, Electrodeposition of amorphous Fe-Cr-Ni stainless steel alloy with high corrosion resistance, low cytotoxicity and soft magnetic properties, Surface and Coatings Technology, accepted, 2018.
K. Keevend, G. Panzarasa, F.H.L Starsich, M. Zeltner, A. Spyrogianni, E. Tsolaki, G. Fortunato, S.E. Pratsinis, S. Bertazzo, I.K. Herrmann*, Facile meltPEGylation of Flame-made Luminescent Tb3+-dopedYttrium Oxide Particles: Hemocompatibility, Cellular Uptake and Comparison to Silica, Chemical Communications, accepted, 2018, 54, 2914-2917. *senior and corresponding author
A. Spyrogianni, P. Tiefenboeck, F. Starsich, K. Keevend, F. Krumeich, I.K. Herrmann, J.C. Leroux, G. Sotiriou, Near-UV activated, photostable nanophosphors for in vitro dosimetry and dynamic bioimaging, AIChE Journal, accepted, 2018.
N. Bohmer, N. Demarmels, E. Tsolaki, L. Gerken, K. Keevend, S. Bertazzo, M. Lattuada, I.K. Herrmann*, Removal of Cells from Body Fluids by Magnetic Separation in Batch and Continuous Mode: Influence of Bead Size, Concentration, and Contact Time, ACS Applied Material and Interfaces. 2017. doi: 10.1021/acsami.7b10140. *senior and corresponding author
A. Spyrogianni, I.K. Herrmann, K. Keevend, S.E. Pratsinis, K. Wegner, The silanol content and in vitro cytolytic activity of flame-made silica, Journal of Colloid and Interface Science. 507:95-106 (2017).
M.T. Matter, F. Starsich, M. Galli, M. Hilber, A.A. Schlegel, S. Bertazzo, S.E. Pratsinis, I.K. Herrmann*, Developing a tissue glue by engineering the adhesive and hemostatic properties of metal oxide nanoparticles, Nanoscale, 9(24):8418-8426 (2017). *senior and corresponding author. Altmetric Top 5%!
G. Fuhrmann, A.L. Neuer, I.K. Herrmann, Extracellular vesicles - a promising avenue for the detection and treatment of infectious diseases, European Journal of Pharmaceutics and Biopharmaceutics, 10.1016/j.ejpb.2017.04.005. (2017). (Invited).
K. Keevend, M. Stiefel, A.L. Neuer, M.T. Matter, A. Neels, S. Bertazzo, I.K. Herrmann*, Tb3+-doped LaF3 nanocrystals for correlative cathodoluminescence electron microscopy imaging with nanometric resolution in focus ion beam-sectioned biological samples, Nanoscale, 30;9(13):4383-4387 (2017). *senior and corresponding author ** featured on the Back Cover of Nanoscale. Altmetric Top 25%!
M. Rösslein, N. Liptrott, A. Owen, P. Boisseau, P. Wick, I.K. Herrmann*, Sound Understanding of Environmental, Health and Safety, Clinical, and Market Aspects is Imperative to Clinical Translation of Nanomedicines, Nanotoxicology, 11(2):147-149 (2017). *senior and corresponding author
M. Lattuada, Q. Ren, F. Zuber, M. Galli, N. Bohmer, M.T. Matter, A. Wichser, S. Bertazzo, G.B. Pier, I.K. Herrmann*, Theranostic Body Fluid Cleansing: Rationally designed magnetic particles enable capturing and detection of bacterial pathogens, Journal of Materials Chemistry B, 4, 7080—7086 (2016) *senior and corresponding author ** featured on the Back Cover of J. Mater. Chem. B, 2016, 4, 7169-7170. *** featured in international newspapers and radio shows, including the Omega Watches Lifetime Magazine, Nanowerk, Deutschlandfunk, etc. Altmetric Top 5%!
Q. Flamant, C. Caravaca, S. Meille, L. Grémillard, J. Chevalier, K. Biotteau, M. Kuntz, R. Chandrawati, I.K. Herrmann, C.D. Spicer, M.M. Stevens, M. Anglada, Selective etching of injection molded zirconia toughened alumina: towards osseointegrated and antibacterial ceramic implants, Acta Biomaterialia, 46, 308-322 (2016).
A. Spyrogianni, I. K. Herrmann, M. S. Lucas, J-C. Leroux, G. A. Sotiriou. Quantitative analysis of the deposited nanoparticle dose on cell cultures by optical absorption spectroscopy, Nanomedicine, 11(19):2483-96 (2016).
I.K. Herrmann*, B. Beck-Schimmer, C.M. Schumacher, S. Gschwind, A. Kaech, U. Ziegler, P.A. Clavien, D. Günther, W.J. Stark, R. Graf, A.A. Schlegel, In vivo risk evaluation of carbon-coated iron carbide nanoparticles based on short and long-term exposure scenarios, Nanomedicine, 11(7):783-96, (2016). *corresponding author
I.K. Herrmann* and M. Rösslein, Personalized Medicine: The enabling Role of Nanotechnology, Nanomedicine, 11(1):1-3 (2016). *corresponding author. *one of the most accessed articles of 2016 across all Future Medicine journals (Editorial)
M. Jacobson, B. Roth Z'graggen, S. Graber, C.M. Schumacher, W.J. Stark, C. Dumrese, J. Mateos, C. Aemisegger, U. Ziegler, M. Urner, I.K. Herrmann*, B. Beck-Schimmer*, Uptake of Ferromagnetic Carbon-encapsulated Metal Nanoparticles in Endothelial Cells: Influence of Shear Stress and Endothelial Activation, Nanomedicine, 10(24):3537-46 (2015). **co-senior author
C.S. Almeida, I.K. Herrmann, P. Howes, M.M. Stevens, Tailoring cellular uptake of conjugated polymer nanoparticles using modular amphiphilic peptide capping ligands, Chemistry of Materials, 27(19), 6879–6889, (2015).
I.K. Herrmann*, S. Bertazzo, D.J.P. O’Callaghan, A. Schlegel, C. Kallepitis, D. Antcliffe, A.C. Gordon, M.M. Stevens*, Differentiating Sepsis from Non-Infectious Systemic Inflammation based on Microvesicle-Bacteria Aggregation, Nanoscale, 7(32):13511-20 (2015). *corresponding author
G. Fuhrmann, I.K. Herrmann, M.M. Stevens, Cell-derived vesicles for drug therapy and diagnostics: opportunities and challenges, Nano Today, 10 (3), 397–409 (2015). (Invited Review)
I.K. Herrmann, A. Schlegel, R. Graf, W.J. Stark, B. Beck-Schimmer, Magnetic Separation-Based Blood Purification: A Promising New Approach for the Removal of Disease-causing Compounds, Journal of Nanobiotechnology, 13:49 (2015). (Perspective).
M. Urner, M. Schläpfer, I.K. Herrmann, M. Hasler, R.C. Schimmer, C. Booy, B. Roth-Z’graggen, H. Rehrauer, F. Aigner, R.D. Minshall, W.J. Stark, B. Beck-Schimmer, Insight into the beneficial immunomodulatory mechanism of the sevoflurane metabolite hexafluoro-2-propanol in a rat model of endotoxemia, Clinical and Experimental Immunology, 181(3):468-479 (2015).
I.K. Herrmann*, How Nanotechnology-enabled concepts could contribute to the prevention, diagnosis and therapy of bacterial infections, Critical Care, 19, 239-241, 2015. *corresponding author. (Viewpoint article) *highly-accessed
L. Bircher, O.M. Theusinger, S. Locher, P. Eugster, B. Roth-Z’graggen, C.M. Schumacher, J.-D. Studt, W.J. Stark, B. Beck-Schimmer, I.K. Herrmann*, Characterization of Carbon-Coated Magnetic Nanoparticles using Clinical Blood Coagulation Assays: Effect of PEG-Functionalization and Comparison to Silica Nanoparticles, Journal of Materials Chemistry B, 2, 3753-58 (2014). *corresponding author.
R. Fuhrer, S. Hofmann, N. Hild, J.R. Vetsch, I.K. Herrmann, R.N. Grass, W.J. Stark, Pressureless Mechanical Induction of Stem Cell Differentiation is Dose and Frequency Dependent, PLoS One, 8(11), e81362 (2013).
I.K. Herrmann*, A. Schlegel, R. Graf, C.M. Schumacher, N. Senn, S. Gschwind, A.M. Hirt, D. Günther, P.-A. Clavien, W.J. Stark, B. Beck-Schimmer, Nanomagnet-based removal of lead and digoxin from living rats, Nanoscale, 5(18), 8718-23 (2013). *corresponding author. Featured in RSC Chemistry World (most read article in July 2013), RSC blog, Materials360online and the Swiss Innovation Report issued by the Swiss Government (SER).
I.K. Herrmann, M. Castellon, D.E. Schwartz, M. Hasler, M. Urner, G. Hu, R.D. Minshall, B. Beck-Schimmer, Intravenous Hexafluoroisopropanol Application improves Outcome in Murine Septic Peritonitis, PLoS One, 8(8), e72057 (2013).
I.K. Herrmann, M. Castellon, D.E. Schwartz, M. Hasler, M. Urner, G. Hu, R.D. Minshall, B. Beck-Schimmer, Volatile Anesthetics Improve Survival after Cecal Ligation and Puncture, Anesthesiology, 119(4), 901-6 (2013). Featured in editorial views.
C.M. Schumacher, I.K. Herrmann, S.B. Bubenhofer, S. Gschwind, A.M. Hirt, B. Beck-Schimmer, D. Günther and W.J. Stark, Quantitative Recovery of Magnetic Nanoparticles from Flowing Blood: Trace Analysis and the Role of Magnetization, Advanced Functional Materials, 23(39), 4888-96 (2013). Featured on cover of the Advanced Functional Materials, 23(39), 1, 2013. Featured in Materials Views.
I.K. Herrmann, M. Urner, S. Graf, C.M. Schumacher, B. Roth-Z’Graggen, M. Hasler, W.J. Stark, B. Beck-Schimmer, Endotoxin Removal by Magnetic Separation-based Blood Purification, Advanced Healthcare Materials, 2(6), 829-35 (2013). Featured as frontispiece image in Advanced Healthcare Materials, 2(6), 828 (2013).
M. Urner, I.K. Herrmann, C. Booy , B. Roth-Z’Graggen, M. Maggiorini, B. Beck-Schimmer, Effect of Hypoxia and Dexamethasone on Inflammation and Ion Channel Function in Lung Cells, Clinical and Experimental Immunology, 169(2), 119-28 (2012).
M. Urner, I.K. Herrmann, F. Buddeberg, C. Schuppli , B. Roth-Z’Graggen, M. Hasler, U. Schanz, M. Mehr, D.R. Spahn, B. Beck-Schimmer, Effects of Blood Products on Inflammatory Response in Endothelial Cells in vitro, PLoS One, 7(3), e33403 (2012).
I.K. Herrmann, M. Urner, M. Hasler, B. Roth-Z’Graggen, C. Aemisegger, W. Baulig, E.K. Athanassiou, S. Regenass, W.J. Stark, B. Beck-Schimmer, Iron Core/Shell Nanoparticles as Magnetic Drug Carriers: Possible Interactions with the Vascular Compartment, Nanomedicine, 6, 1199-1213 (2011).
M. Urner, L.K. Limbach, I.K. Herrmann, W.J. Stark, B. Beck-Schimmer, Fluorinated carbon groups mediate the immunomodulatory effects of volatile anesthetics, American Journal of Respiratory Cell and Molecular Biology, 45(3), 617-24 (2011).
I.K. Herrmann, R.E. Bernabei, M. Urner, R.N. Grass, B. Beck-Schimmer, W.J. Stark, Device for Continuous Extracorporeal Blood Purification using Target-specific Metal Nanomagnets, Nephrology Dialysis Transplantation, 26 (9), 2948-2954 (2011). Featured in MIT Technology Report Review, various international newspapers and TV shows (BR, ARD (Germany), arte (France), SF2 (Switzerland).
R. Fuhrer, I.K. Herrmann, E.K. Athanassiou, W.J. Stark, Immobilized β-Cyclodextrin on carbon coated cobalt nanomagnets: reversible organic contaminant adsorption and enrichment from water, Langmuir, 27(5), 1924-9 (2011).
I.K. Herrmann, M. Urner, F.M. Koehler, M. Hasler, B. Roth Z’Graggen, R.N. Grass, U. Ziegler, B. Beck-Schimmer, W.J. Stark, Blood Purification using Core/Shell Nanomagnets, Small, 6 (13) 1388-1392 (2010). Featured in Nature Nanotechnology, 5, 628 (2010).
I.K. Herrmann, R.N. Grass, W.J. Stark, High-strength metal nanomagnets for diagnostics and medicine: carbon shells allow long-term stability and reliable linker chemistry, Nanomedicine, 4(7):787-98 (2009).
I.K. Herrmann, R.N. Grass, D. Mazunin, W.J. Stark, Synthesis and Covalent Surface Functionalization of Nonoxidic Iron Core-Shell Nanomagnets, Chemistry of Materials, 21(14), 3275-81 (2009).
J Mater Chem Back Cover
Prof. Dr. Inge Katrin Herrmann
Chemical Engineering, Particle Synthesis and Functionalization, Bioimaging, Translational ResearchPhone: +41 58 765 7153
11/21 Congrats Alice on your new job - she is going to be a professor at top-tier uni in France!
11/21 Massive congratulations to Alex Anthis on winning Empa's Research Award 2021 with his Adv Funct Mater paper!
10/21 Inge wins the ETH Dandelion Special Award for championing interdisciplinary collaboration and entrepreneurship!
07/21 Congrats to our postdoc Fabian on winning an ETH career seed grant and an SNF International Visit Fellowship for Hamburg!
07/21 Lockdown project paper on extracellular vesicles together with Gregor Fuhrmann and Matthew Wood is finally out in Nature Nano!
06/21 Congrats Alex on winning an ETH Pioneer Fellowship with AnastoSEAL!
06/21 Congrats anavo on winning the Swiss Nanotech Startup of the year award at the Swiss NanoConvention 2021!
06/21 Anavo was selected as the winner of this year's startup days Healtech startup!
06/21 Congrats to Tino Matter on winning the ETH MaP Award 2021 for his doctoral research!
05/21 Congrats Alex on a very successful doctoral defense and on winning the Chemistry Travel Award 2021 awarded by the Swiss Chemical Society just the day after the defense.
02/21 Tino and Inge's paper accepted in Nanoscale and featured in the Emerging Investigator Issue 2021!
12/20 Check out the blog post and seminar on CCLEM and Kerda's work by Delmic!
12/20 We won the Empa Innovation Award 2020 with our nanoglue technology!
11/20 The Gebauer Foundation supports our newest research endeavours! We are excited!
11/20 Inge joins the Executive Board of the ETH SFA Personalized Health and Related Technologies Program and the ETH AI Center as Affiliated Faculty.
11/20 Delighted that our Innosuisse project with Hemotune on developing a new method to detect nanoparticles in tissue has been approved!
11/20 Hemotune and Anavo (formerly Nanoglue) are both are in the finals of the Swiss Technology Award! Congratulations
10/20 Fabian's article Precision in thermal therapy: clinical requirements and solutions from nanotechnology accepted in Advanced Therapeutics! #openaccess
09/20 Congrats Alex on the acceptance of your Advanced Functional Materials paper!
09/20 Tino's doctoral defense
09/20 Kerda's 5th first author manuscript from her PhD accepted for publication in Small!
09/20 Congrats Alex on winning The Future of Health Ideas Competition! Congrats Alex!!
07/20 Congrats Tino on winning an ETH Pioneer Fellowship!
08/20 Tino's contribution to the Pharmaceutics Special Issue on Hybrid Multifunctional Drug Delivery Systems accepted. Great collaboration with two leading wound care specialists from Zurich and Geneva. Congrats Tino!
07/20 Kerda's paper on cathodoluminescence bioimaging accepted in Nanoscale! Great collaboration with Toon Coenen from Delmic/AMOLF. Congrats Kerda!
06/20 Check out Elena's latest work on breast cancer-specific minerals on biorxiv!
05/20 Anna's paper accepted in Nanoscale Adv! Congrats Anna, Lukas, Kerda & Alex!
05/20 Tino's paper accepted in Advanced Science!! Congrats Tino, Jian & Kerda!
04/20 Paper together with PTL accepted in Advanced Science! Congrats Pascal & Lukas!
02/20 Watch Inge's Inagural Lecture at ETH Zurich online!
01/20 Congratulations Anna on the best presentation award (2nd prize) at the Young Scientist Symposium SBB+RM at ETH!
01/20 Paper on heloderma suspectum (gila monster) accepted in Acta Biomaterialia! Great collaboration with various groups from UCL.
12/19 Happy holidays everyone!
12/19 Delighted that the Krebsliga supports our precision radiotherapy project!
12/19 Congrats Tino on the best presentation award (2nd prize) at the Empa PhD Symposium 2019!
11/19 Alex' 2nd first author manuscript of this year got accepted for publication in ACS AMI! Congrats Alex!!
11/19 Super happy that our immunoCCLEM project got funded by the SNF SPARK program!
11/19 Tino wins Amercian Institute of Chemical Engineering Annual Meeting (AIChE 2019) Graduate Student Award (2nd prize, Inorganic Materials)! Congrats Tino!
11/19 Alex' paper featured on the front cover of Analyst!
11/19 10 oral presentations by our lab at the AIChE Annual 2019! Great discussions and feedback!
11/19 Kerda successfully defended her PhD on Nov 7, the night before we left to Miami/Orlando, FL for the AIChE Annual Meeting! Congrats Kerda!!!
10/19 Nanoglue successfully completed VentrureKick stage II!
09/19 Alex' paper on mineral characterization in human placenta tissue (together with UCL and KSSG) accepted in Analyst. Congrats Alex!
08/19 Kerda's paper on correlative cathodoluminescence electron microscopy accepted in Nano Letters! Congrats Kerda, Lukas, Tino and Jian-Hao!
07/19 Nanoglue is part of VentureKick!
06/19 We are grateful to the OPO Foundation for supporting our project with the Immunobiology Lab at the local hospital (KSSG)!
05/19 Welcome to the new PhD students Subas and Anna!
03/19 Tino's startup Nanoglue made it into the top6 at the European Startup Summit! Congrats Tino!
12/18 Tino's paper on ceria bioactivity accepted in ACS AMI! Congrats Tino and Lea!
12/18 Lukas' paper on radioenhancement in collaboration with the ETH and the University Hospital Zurich accepted in ACS AMI! Congrats Lukas, Kerda and Tino!
11/18 Swiss National Science Foundation Eccellenza Award 2018!
11/18 Delighted that our grant application together with Dr Bertazzo (UCL), Prof. Obrist (ARTORG), Prof. Carrel (Inselspital) and Prof. Thürlimann (KSSG) is supported by the ETH Personalized Health and Related Technologies (PHRT) program!
11/18 Kerda was the chairwoman of this year's PhD symposium with more participants than ever before! Well done Kerda!
11/18 Tino and Ioana's nanoglue paper in collaboration with the Plastic and Reconstructive Surgery Department (University Hospital Bern) accepted!
10/18 Tino's research & master thesis award featured by SNI!
08/18 We are grateful to the Novartis FreeNovation Program and the Olga Mayenfisch Foundation for supporting our research activities!
08/18 Joint paper with ETH's PTL and the USZ - check it out here!
06/18 - Joint paper with our colleagues from Thun on electrodeposited steel has been accepted for publication in Surface & Coatings Technology
03/18 - Tino's research on surgical glues featured on international TV program (ZDF). Aired April 9!
03/18 - Joint paper with the Sotiriou lab at Karolinska on dynamic bioimaging accepted!
02/18 - Kerda's meltPEGylation manuscript has been accepted for publication in Chem Comm! Check it out here!
12/17- We are very grateful to the Bangerter Rhyner Foundation, Helmut Horten Stiftung, Novartis, the Swiss Heart Foundation and the SNF for supporting our research in the coming years!
12/17 - Tino has won the Award for the Best Master Thesis in Nanoscience (Swiss Nanoscience Institute, SNI, University of Basel) for his thesis work on surgical adhesives in our group at Empa. Congratulations!!!
11/17 - Kerda has won the Best Oral Presentation Award at the 2017 Empa PhD Symposium! Congrats!!!
05/17 - Watch the Magnetic Blood Purification Revisited! lecture given at last year's CLINAM!
03/17 - Kerda's Correlative cathodoluminescene electron microscopy (CCLEM) paper featured on the back cover of Nanoscale!
11/16 - Kerda Keevend has been awarded a Best Oral Presentation Award for her presentation on correlative bioimaging at the 2016 PhD symposium. Congratulations Kerda!
MRS Fall Meeting 2021
Swiss Nanoconvention 2021
GRC Semiconductor Nanocrystals, July 5-11, 2020, Les Diablerets, Switzerland (Inge)
Swiss Nanoconvention, July 2-3, 2020, Basel, Switzerland (Inge)
CLINAM 2020, May 2020, Basel, Switzerland (Lukas, Fabian, Inge)
Magentic Particle Imaging Workshop, Mar 30-Apr 2, 2020, Würzburg (Fabian, Subas, Inge)
Schweizerischer Kongress für Nephrologie, Interlaken, Dez 5-6, 2019 (Inge)
Amercian Institute of Chemical Engineering Annual Meeting (AIChE 2019), Orlando (FL), Nov 10-15, 2019 (all)
GRC Cancer Nanotech 2019 (Lukas)
The German Pharmacy Annual Meeting, Hamburg Oct 2-4, 2018 (Inge)
CLINAM, Basel, Sept 3-5, 2018 (Inge, Monday only)
the Biointerfaces International Conference 2018 in Zurich, Aug 14-16, 2018 (Kerda and Tino)
the GRC on Personalized Medicine 2018 in Hong Kong, July 29-Aug 3, 2018 (Inge)
the GRC on Bioanalytical Sensors 2018 in New Port, USA, June 24-29, 2018 (Kerda)
the Nanomedicine Conference in Rome, 2018 (Inge)
the Cathodoluminescene Workshop organized by DELMIC in Amsterdam, May 30, 2018 (Kerda and Inge)
the BioX Conference at Empa, March 16, 2018
the MRS Fall Meeting, in Boston, US, Nov 28 - Dec 5, 2017 (Tino)
the Gordon Research Conference on Nanomechanical Interfaces, in Hong Kong, China, July 31 - Aug 5, 2017 (Tino)
the Swiss Surgical Society Annual Meeting, in Bern, Switzerland, May 31 to June 2, 2017 (Tino)
the European Summit for Clinical Nanomedicine (CLINAM), in Basel, Switzerland, May 7-10, 2017 (Kerda & Inge)
the European Nanomedicine Meeting, in London, UK, April 2-3, 2017 (Inge)
the Fifth International Conference on Multifunctional, Hybrid and Nanomaterials in Lisbon, Portugal, March 6-10, 2017 (Kerda & Inge)
the European Summit for Clinical Nanomedicine (CLINAM) in Basel, Switzerland, June 27-30, 2016
the Gordon Research Conference (GRC) on Personalized Medicine, Hong Kong, China, July 10-15, 2016
the inet Technology Circle Nanomedicine in Basel, Switzerland, August 30, 2016