Multi-omics for healthcare materials
The group Multi-omics for healthcare materials focuses on deconvolution of disease-associated cellular signaling networks in order to inform precise imunoengineering solutions. Activities of the group are centered on generating and analyzing biomedical multi-omics datasets that can assist development of new materials for personalized healthcare applications.
Our research work aims to enable rational design of new materials by capitalizing on large-scale biomedical datasets. This involves development of new software tools, employment of advanced data analytics and modeling of material properties. Through collaborations with material scientists, we evaluate the efficiency of the in silico designed functionalized nanoparticles and other modified materials. Together with clinical and industrial partners, we seek to implement these new concepts into next generation healthcare solutions.
Signaling in tumor microenvironment
Signaling pathways in disease cells
Nanoparticles as drug delivery systems
Alma Mater: UZH
Delia Cella, MSc Student
Alma Mater: ETH
Benoit Hohl, MSc Student
Alma Mater: EPFL
Emile Bourban, MSc Student
Alma Mater: EPFL
M Buljan, R Ciuffa, A van Drogen, A Vichalkovski, M Mehnert, G Rosenberger, S Lee, M Varjosalo, L Espona Pernas, V Spegg, B Snijder, R Aebersold*, M Gstaiger*: Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases. Molecular cell 79(3):504-520. (2020)
M Buljan, P Blattmann, R Aebersold*, M Boutros*: Systematic characterization of pan-cancer mutation clusters. Molecular systems biology 14(3): e7974. (2018)
JK White, AK Gerdin, NA Karp, E Ryder, M Buljan, JN Bussell, J Salisbury, S Clare, NJ Ingham, C Podrini, R Houghton, J Estabel, JR Bottomley, DG Melvin, D Sunter, NC Adams, L Baker, C Barnes, R Beveridge, E Cambridge, D Carragher, P Chana, K Clarke, Y Hooks, N Igosheva, C Ismail, H Jackson, L Kane, R Lacey, DT Lafont, M Lucas, S Maguire, K McGill, RE McIntyre, S Messager, L Mottram, L Mulderrig, S Pearson, HJ Protheroe, LA Roberson, G Salsbury, M Sanderson, D Sanger, C Shannon, PC Thompson, E Tuck, VE Vancollie, L Brackenbury, W Bushell, R Cook, P Dalvi, D Gleeson, B Habib, M Hardy, K Liakath-Ali, E Miklejewska, S Price, D Sethi, E Trenchard, D von Schiller, S Vyas, AP West, J Woodward, E Wynn, A Evans, D Gannon, M Griffiths, S Holroyd, V Iyer, C Kipp, M Lewis, W Li, D Oakley, D Richardson, D Smedley, C Agu, J Bryant, L Delaney, NI Gueorguieva, H Tharagonnet, AJ Townsend, D Biggs, E Brown, A Collinson, CE Dumeau, E Grau, S Harrison, James Harrison, Catherine E Ingle, Helen Kundi, Alla Madich, Danielle Mayhew, T Metcalf, S Newman, J Pass, L Pearson, H Reynolds, C Sinclair, H Wardle-Jones, M Woods, L Alexander, T Brown, F Flack, C Frost, N Griggs, S Hrnciarova, A Kirton, J McDermott, C Rogerson, G White, P Zielezinski, T DiTommaso, A Edwards, E Heath, MA Mahajan, B Yalcin, D Tannahill, DW Logan, DG MacArthur, J Flint, VB Mahajan, SH Tsang, I Smyth, FM Watt, WC Skarnes, G Dougan, DJ Adams, R Ramirez-Solis, A Bradley, KP Steel: Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell 154(2):452-464. (2013)M Buljan*, G Chalancon, S Eustermann, GP Wagner, M Fuxreiter, A Bateman, MM Babu*: Tissue-specific splicing of disordered segments that embed binding motifs rewires protein interaction networks. Molecular cell 46(6): 871-883. (2012)
We are looking for a PhD and a Master student to join the group.
Regardless of open calls, if you are interested to join the lab as a PhD student or a Postdoctoral fellow and are eligible for an independent fellowship, please get in touch!
The group has now joined the Swiss Institute of Bioinformatics!
Frontiers in Molecular Biosciences are inviting manuscript submissions for a special issue on alternative splicing. We are co-editing the issue.