Publications 2020

Beyeler, S.; Steiner, S.; Wotzkow, C.; Tschanz, S. A.; Adhanom Sengal, A.; Wick, P.; Haenni, B.; Alves, M. P.; von Garnier, C.; Blank, F. Multi-walled carbon nanotubes activate and shift polarization of pulmonary macrophages and dendritic cells in an in vivo model of chronic obstructive lung disease. Nanotoxicology 2020, 14 (1), 77-96. https://doi.org/10.1080/17435390.2019.1663954
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Borchard, G.; Som, C.; Zinn, M.; Ostafe, V.; Borges, O.; Perale, G.; Wick, P. Editorial: Polymeric nano-biomaterials for medical applications: advancements in developing and implementation considering safety-by-design concepts. Frontiers Bioeng. Biotechnol. 2020, 8, 599950 (2 pp.). https://doi.org/10.3389/fbioe.2020.599950
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Buljan, M.; Ciuffa, R.; van Drogen, A.; Vichalkovski, A.; Mehnert, M.; Rosenberger, G.; Lee, S.; Varjosalo, M.; Pernas, L. E.; Spegg, V.; et al. Kinase interaction network expands functional and disease roles of human kinases. Mol. Cell 2020, 79 (3), 504-520. https://doi.org/10.1016/j.molcel.2020.07.001
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Cassano, J. C.; Roesslein, M.; Kaufmann, R.; Luethi, T.; Schicht, O.; Wick, P.; Hirsch, C. A novel approach to increase robustness, precision and high-throughput capacity of single cell gel electrophoresis. ALTEX 2020, 37 (1), 95-109. https://doi.org/10.14573/altex.1906252
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Dauth, S.; Rakov, H.; Sîrbulescu, R. F.; Ilieş, I.; Weber, J.; Batbajar Dugershaw, B.; Braun, D.; Rehders, M.; Wirth, E. K.; Führer, D.; et al. Function of cathepsin K in the central nervous system of male mice is independent of its role in the thyroid gland. Cell. Mol. Biol. 2020, 40, 695-710. https://doi.org/10.1007/s10571-019-00765-6
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Dugershaw, B. B.; Aengenheister, L.; Schmidt Kjølner Hansen, S.; Sørig Hougaard, K.; Buerki-Thurnherr, T. Recent insights on indirect mechanisms in developmental toxicity of nanomaterials. Part. Fibre Toxicol. 2020, 17 (1), 31 (22 pp.). https://doi.org/10.1186/s12989-020-00359-x
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Franz, P.; Bürkle, A.; Wick, P.; Hirsch, C. Exploring flow cytometry-based micronucleus scoring for reliable nanomaterial genotoxicity assessment. Chem. Res. Toxicol. 2020, 33 (10), 2538-2549. https://doi.org/10.1021/acs.chemrestox.0c00071
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Gogos, A.; Wielinski, J.; Voegelin, A.; von der Kammer, F.; Kaegi, R. Quantification of anthropogenic and geogenic Ce in sewage sludge based on Ce oxidation state and rare earth element patterns. Water Res. X 2020, 9, 100059 (8 pp.). https://doi.org/10.1016/j.wroa.2020.100059
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Gschwend, P. M.; Niedbalka, D.; Gerken, L. R. H.; Herrmann, I. K.; Pratsinis, S. E. Simultaneous nanothermometry and deep-tissue imaging. Adv. Sci. 2020, 7 (12), 200370 (6 pp.). https://doi.org/10.1002/advs.202000370
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Hempt, C.; Gontsarik, M.; Buerki-Thurnherr, T.; Hirsch, C.; Salentinig, S. Nanostructure generation during milk digestion in presence of cell culture models simulating the small intestine. J. Colloid Interface Sci. 2020, 574, 430-440. https://doi.org/10.1016/j.jcis.2020.04.059
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Hempt, C. Safety and uptake assessment of nanostructured silica in an advanced intestinal in vitro model. Doctoral dissertation, ETH Zurich, Zurich, Switzerland, 2020, 224 p. https://doi.org/10.3929/ethz-b-000425993
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Hempt, C.; Kaiser, J. P.; Scholder, O.; Buerki-Thurnherr, T.; Hofmann, H.; Rippl, A.; Schuster, T. B.; Wick, P.; Hirsch, C. The impact of synthetic amorphous silica (E 551) on differentiated Caco-2 cells, a model for the human intestinal epithelium. Toxicol. Vitro 2020, 67, 104903 (14 pp.). https://doi.org/10.1016/j.tiv.2020.104903
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Iacoviello, F.; Kirby, A. C.; Javanmardi, Y.; Moeendarbary, E.; Shabanli, M.; Tsolaki, E.; Sharp, A. C.; Hayes, M. J.; Keevend, K.; Li, J. H.; et al. The multiscale hierarchical structure of Heloderma suspectum osteoderms and their mechanical properties. Acta Biomater. 2020, 107, 194-203. https://doi.org/10.1016/j.actbio.2020.02.029
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Inderbinen, S. G.; Engeli, R. T.; Rohrer, S. R.; Di Renzo, E.; Aengenheister, L.; Buerki-Thurnherr, T.; Odermatt, A. Tributyltin and triphenyltin induce 11β-hydroxysteroid dehydrogenase 2 expression and activity through activation of retinoid X receptor α. Toxicol. Lett. 2020, 322, 39-49. https://doi.org/10.1016/j.toxlet.2020.01.001
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Iranpour Anaraki, N.; Sadeghpour, A.; Iranshahi, K.; Toncelli, C.; Cendrowska, U.; Stellacci, F.; Dommann, A.; Wick, P.; Neels, A. New approach for time-resolved and dynamic investigations on nanoparticles agglomeration. Nano Res. 2020, 13 (10), 2847-2856. https://doi.org/10.1007/s12274-020-2940-4
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Jesus, S.; Marques, A. P.; Duarte, A.; Soares, E.; Costa, J. P.; Colaço, M.; Schmutz, M.; Som, C.; Borchard, G.; Wick, P.; et al. Chitosan nanoparticles: shedding light on immunotoxicity and hemocompatibility. Frontiers Bioeng. Biotechnol. 2020, 8, 100 (20 pp.). https://doi.org/10.3389/fbioe.2020.00100
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Keevend, K.; Coenen, T.; Herrmann, I. K. Correlative cathodoluminescence electron microscopy bioimaging: towards single protein labelling with ultrastructural context. Nanoscale 2020, 12 (29), 15588-15603. https://doi.org/10.1039/d0nr02563a
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Keevend, K.; Krummenacher, R.; Kungas, E.; Gerken, L. R. H.; Gogos, A.; Stiefel, M.; Herrmann, I. K. Correlative cathodoluminescence electron microscopy: immunolabeling using rare‐earth element doped nanoparticles. Small 2020, 16 (44), 2004615 (10 pp.). https://doi.org/10.1002/smll.202004615
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Matter, M. T.; Li, J. H.; Lese, I.; Schreiner, C.; Bernard, L.; Scholder, O.; Hubeli, J.; Keevend, K.; Tsolaki, E.; Bertero, E.; et al. Multiscale analysis of metal oxide nanoparticles in tissue: insights into biodistribution and biotransformation. Adv. Sci. 2020, 7 (15), 2000912 (11 pp.). https://doi.org/10.1002/advs.202000912
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Matter, M. T.; Probst, S.; Läuchli, S.; Herrmann, I. K. Uniting drug and delivery: metal oxide hybrid nanotherapeutics for skin wound care. Pharm. 2020, 12 (8), 780 (17 pp.). https://doi.org/10.3390/pharmaceutics12080780
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Milosevic, A.; Romeo, D.; Wick, P. Understanding nanomaterial biotransformation: an unmet challenge to achieving predictive nanotoxicology. Small 2020, 16 (36), 1907650 (5 pp.). https://doi.org/10.1002/smll.201907650
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Mählitz, P. M.; Korf, N.; Sperlich, K.; Münch, O.; Rösslein, M.; Rotter, V. S. Characterizing the urban mine - simulation-based optimization of sampling approaches for built-in batteries in WEEE. Recycl. 2020, 5 (3), 19 (25 pp.). https://doi.org/10.3390/recycling5030019
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Nelson, B. C.; Minelli, C.; Doak, S. H.; Roesslein, M. Emerging standards and analytical science for nanoenabled medical products. Ann. Rev. Anal. Chem. 2020, 13 (1), 431-452. https://doi.org/10.1146/annurev-anchem-091619-102216
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Netkueakul, W.; Korejwo, D.; Hammer, T.; Chortarea, S.; Rupper, P.; Braun, O.; Calame, M.; Rothen-Rutishauser, B.; Buerki-Thurnherr, T.; Wick, P.; et al. Release of graphene-related materials from epoxy-based composites: characterization, quantification and hazard assessment in vitro. Nanoscale 2020, 12 (19), 10703-10722. https://doi.org/10.1039/c9nr10245k
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Neuer, A. L.; Gerken, L. R. H.; Keevend, K.; Gogos, A.; Herrmann, I. K. Uptake, distribution and radio-enhancement effects of gold nanoparticles in tumor microtissues. Nanoscale Adv. 2020, 2 (7), 2992 (10 pp.). https://doi.org/10.1039/D0NA00256A
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Nikravesh, N.; Borchard, G.; Hofmann, H.; Philipp, E.; Flühmann, B.; Wick, P. Factors influencing safety and efficacy of intravenous iron-carbohydrate nanomedicines: from production to clinical practice. Nanomed. Nanotechnol. Biol. Med. 2020, 26, 102178 (11 pp.). https://doi.org/10.1016/j.nano.2020.102178
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Petersen, E. J.; Hirsch, C.; Elliott, J. T.; Krug, H. F.; Aengenheister, L.; Arif, A. T.; Bogni, A.; Kinsner-Ovaskainen, A.; May, S.; Walser, T.; et al. Cause-and-effect analysis as a tool to improve the reproducibility of nanobioassays: four case studies. Chem. Res. Toxicol. 2020, 33 (5), 1039-1054. https://doi.org/10.1021/acs.chemrestox.9b00165
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Romeo, D.; Salieri, B.; Hischier, R.; Nowack, B.; Wick, P. An integrated pathway based on in vitro data for the human hazard assessment of nanomaterials. Environ. Int. 2020, 137, 105505 (12 pp.). https://doi.org/10.1016/j.envint.2020.105505
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Salieri, B.; Kaiser, J. P.; Rösslein, M.; Nowack, B.; Hischier, R.; Wick, P. Relative potency factor approach enables the use of in vitro information for estimation of human effect factors for nanoparticle toxicity in life-cycle impact assessment. Nanotoxicology 2020, 14 (2), 275-286. https://doi.org/10.1080/17435390.2019.1710872
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Schmutz, M.; Borges, O.; Jesus, S.; Borchard, G.; Perale, G.; Zinn, M.; Sips, Ä. A. J. A. M.; Soeteman-Hernandez, L. G.; Wick, P.; Som, C. A methodological safe-by-design approach for the development of nanomedicines. Frontiers Bioeng. Biotechnol. 2020, 8, 258 (7 pp.). https://doi.org/10.3389/fbioe.2020.00258
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Schmutz, M.; Hischier, R.; Batt, T.; Wick, P.; Nowack, B.; Wäger, P.; Som, C. Cotton and surgical masks - What ecological factors are relevant for their sustainability? Sustainability 2020, 12 (24), 10245 (13 pp.). https://doi.org/10.3390/su122410245
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Schmutz, M.; Borges, O.; Borchard, G.; Wick, P.; Som, C. Guidelines as a starting point to address the needs of small and medium enterprises regarding the Safe-by-Design of polymeric nanobiomaterials for drug delivery. In Nanomaterials for theranostics and tissue engineering. Techniques, trends and applications; Rossi, F., Rainer, A., Eds.; Micro and nano technologies; Elsevier: Amsterdam, Netherlands, 2020; pp 259-271. https://doi.org/10.1016/B978-0-12-817838-6.00010-3
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Steinmetz, L.; Bourquin, J.; Barosova, H.; Haeni, L.; Caldwell, J.; Milosevic, A.; Geers, C.; Bonmarin, M.; Taladriz-Blanco, P.; Rothen-Rutishauser, B.; et al. Rapid and sensitive quantification of cell-associated multi-walled carbon nanotubes. Nanoscale 2020, 12 (33), 17362-17372. https://doi.org/10.1039/d0nr03330h
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Stoudmann, N.; Schmutz, M.; Hirsch, C.; Nowack, B.; Som, C. Human hazard potential of nanocellulose: quantitative insights from the literature. Nanotoxicology 2020, 14 (9), 1241-1257. https://doi.org/10.1080/17435390.2020.1814440
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Svendsen, C.; Walker, L. A.; Matzke, M.; Lahive, E.; Harrison, S.; Crossley, A.; Park, B.; Lofts, S.; Lynch, I.; Vázquez-Campos, S.; et al. Key principles and operational practices for improved nanotechnology environmental exposure assessment. Nat. Nanotechnol. 2020, 15, 731-742. https://doi.org/10.1038/s41565-020-0742-1
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Thejer, B. M.; Adhikary, P. P.; Kaur, A.; Teakel, S. L.; Van Oosterum, A.; Seth, I.; Pajic, M.; Hannan, K. M.; Pavy, M.; Poh, P.; et al. PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth. BMC Mol. and Cell Biol. 2020, 21, 24 (24 pp.). https://doi.org/10.1186/s12860-020-00256-3
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Wick, P.; Franz, P.; Huber, S. M.; Hirsch, C. Innovative techniques and strategies for a reliable high-throughput genotoxicity assessment. Chem. Res. Toxicol. 2020, 33, 283-285. https://doi.org/10.1021/acs.chemrestox.9b00369
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Wielinski, J.; Femi Marafatto, F.; Gogos, A.; Scheidegger, A.; Voegelin, A.; Müller, C. R.; Morgenroth, E.; Kaegi, R. Synchrotron hard X-ray chemical imaging of trace element speciation in heterogeneous samples: development of criteria for uncertainty analysis. J. Anal. At. Spectrom. 2020, 35 (3), 567 (13 pp.). https://doi.org/10.1039/C9JA00394K
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Polymeric nano-biomaterials for medical applications: advancements in developing and implementation considering safety-by-design concepts; Borchard, G., Borges, O., Ostafe, V., Perale, G., Som, C., Wick, P., Zinn, M., Eds.; Frontiers in bioengineering and biotechnology; Frontiers Media SA.: Lausanne, 2020; 239 p. https://doi.org/10.3389/978-2-88966-256-2
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