Infections are often caused by bacterial biofilms. Bacteria living in biofilms can tolerate much higher antibiotic concentrations compared to planktonic bacteria and survive long enough to evolve antimicrobial resistance (AMR). We aim to investigate how bacteria generate resistant during biofilm formation on medical devices, and utilize the gained knowledge to develop novel antimicrobial strategies to prevent biofilm-associated infection and AMR.
Pseudomonas aeruginosa biofilms treated with antibiotic gentamicin. Upper panel: wild type strain, lower panel: mutant deficient in flagellum formation, green color: living bacteria, red color: dead bacteria. The greater abundance of green cells in the mutant suggests that the flagellum contributes to biofilm-associated antibiotic resistance.
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