Simulating Biological Systems Group

Vision & Mission SimBioSys

What do we do? Physics-based simulations and sensing of transport processes in plant-based food systems and the human body

Why we do this? To reduce food loss in postharvest supply chains, individualize drug delivery systems, and design sustainable drying processes by understanding and steering these systems in-silico

How do we do this?

  • Pioneering mechanistic modeling at multiple scales
  • Bridging the virtual to the real world by multi-parameter sensing
  • Creating digital twins that can live together with their real-world counterpart

Who are we? An interdisciplinary team of mechanical, biomedical and agricultural engineers, food scientists and environmental scientists. 

Where are we at Empa? We are part of the Laboratory for Biomimetic Membranes and Textiles in Empa's Research Focal Area Health and Performance 

Teaching & Outreach


Course @ ETH Zurich on Simulations and Sensors in Agri-Food Supply Chains (full course, MSc, 3 ECTS credits)

Coordinating Empa's Multiphysics Hub (intranet - external page), including the Multiphysics Channel (on YouTube)

Sustainable development goals  






Thijs Defraeye

Group Leader SimBioSys

+41 58 765 4790

Google Scholar - Scopus 

Fresh of the press

Onwude D., Iranshahi K., Martynenko A., Defraeye T. (2021), Electrohydrodynamic drying: Can we scale-up the technology to make dried fruits and vegetables more nutritious and appealing?, Comprehensive Reviews in Food Science and Food Safety. DOI preprint.

Defraeye T.Bahrami F., Rossi R.M. (2021), Inverse mechanistic modeling of transdermal drug delivery for fast identification of optimal model parameters, Frontiers in Pharmacology (12) 641111 DOI preprint.

Shrivastava C., Crenna E., Schudel S., Shoji K., Onwude D., Hischier R., Defraeye T. (2021), To wrap or to not wrap cucumbers?, preprint - submitted.