Simulating Biological Systems Group

Vision & Mission SimBioSys

What do we do? Physics-based simulations and sensing of transport processes in plant-based food systems and the human body

Why we do this? To reduce food loss in postharvest supply chains, individualize drug delivery systems, and design sustainable drying processes by understanding and steering these systems in-silico

How do we do this?

  • Pioneering mechanistic modeling at multiple scales
  • Bridging the virtual to the real world by multi-parameter sensing
  • Creating digital twins that can live together with their real-world counterpart

Who are we? An interdisciplinary team of mechanical, biomedical and agricultural engineers, food scientists and environmental scientists. 

Where are we at Empa? We are part of the Laboratory for Biomimetic Membranes and Textiles in Empa's Research Focal Area Health and Performance 

Teaching & Outreach

Sustainable development goals

SDG website:  






Thijs Defraeye

Group Leader SimBioSys

+41 58 765 4790

Google Scholar - Scopus 

Fresh of the press

Defraeye T.Bahrami F.Ding L.Malini R.I., Terrier A., Rossi R.M. (2020), Predicting transdermal fentanyl delivery using mechanistic simulations for tailored therapy, Frontiers in Pharmacology (11) 585393. DOI preprint on bioRxiv.

Schudel S.Prawiranto K.Defraeye T. (2021), Comparison of freezing and convective dehydrofreezing of vegetables for reducing cell damage, Journal of Food Engineering 293, 110376. DOI

Iranshahi K., Martynenko A., Defraeye T. (2020), Cutting-down the energy consumption of electrohydrodynamic drying by optimizing mesh collector electrode, Energy, 118168DOI