GoNanoBioMat

The aging population represents an enormous financial burden for society, unless ways can be found to maintain independence and quality-of-life (QoL) as long as possible for each individual. To achieve this, novel concepts and technologies for new solutions and products are needed. For example, the use of polymeric nanobiomaterials in medicine might be a solution for answering to this need.

Currently, the number of health applications on the market remains small due to the unclear situation of the future regulatory assessment of efficacy and safety. In this context, the GoBioNanoMat project aims to enable SMEs (small and medium size enterprises) and their suppliers, and Research Institutes to work on the development and production of polymeric nanobiomaterials for drug delivery implementing Safer-by-Design (SbD) approach. The major expected outcomes of this project are:

  1. A verified knowledge base (built on peer-reviewed scientific publications on polymeric nanobiomaterials, their environmental and human health risks and the regulatory aspects.),
  2. and guidelines to implement SbD approach for polymeric nanobiomaterial drug delivery systems
  3. as well as in depth investigation of three selected materials like Chitosan, Polylactic (PLA) acid and Polyhydroxyalkanoates (PHA) regarding drug delivery applications.

The GoNanoBioMat consortium combines expertise in the area of nanobiomaterial science and technology, life science, pharmaceutical science, as well as nanosafety and life cycle thinking. A strong regulatory background and knowledge base building, dissemination and training belong as well to the core competences of this consortium.

 

 

Publications

 

Hauser, M.; Li, G. Y.; Nowack, B. (2019) Environmental hazard assessment for polymeric and inorganic nanobiomaterials used in drug delivery. J. Nanobiotechnol. 17: 56.

 

Special issue in Frontiers Bioengineering and Biotechnology: Polymeric Nano-Biomaterials for Medical Applications: Advancements in Developing and Implementation Considering Safety-By-Design Concepts.

 

Schmutz M., Borges O.,  Jesus S. , Borchard G. , Perale G. , Zinn M. , Sips Ä. ,  Soeteman-Hernandez L. , Wick P. and  Som C. (2020). A Methodological Safe-by-Design Approach for the Development of Nanomedicines, Front. Bioeng. Biotechnol. pdf 

Hauser, M.; Nowack, B. (2019) Meta-analysis of pharmacokinetic studies of nanobiomaterials for the prediction of excretion depending on particle characteristics. Frontiers in Bioengineering and Biotechnology 7: 405. pdf

Jesus, S., Marques, A. P., Duarte, A., Soares, E., Costa, J. P., Colaço, M., Schmutz, M., Som, C., Borchard, G., Wick, P., & Borges, O. (2020). Chitosan nanoparticles: shedding light on immunotoxicity and hemocompatibility. Front. Bioeng. Biotechnol. pdf

Roman D. , Roman M. , Som C. , Schmutz M. , Hernandez E., Wick P. ,  Casalini T., Perale G.,  Ostafe V. and Isvoran A. (2020).  Computational Assessment of the Pharmacological Profiles of Degradation Products of Chitosan,  Front. Bioeng. Biotechnol. pdf

Casalini T. , Limongelli V., Schmutz M. ,  Som C. , Jordan O., Wick P. , Borchard G. and  Perale G.  (2020). Molecular Modeling for Nanomaterial–Biology Interactions: Opportunities, Challenges, and Perspectives, Front. Bioeng. Biotechnol. pdf

Jesus S. , Schmutz M. , Som C. ,  Borchard G. , Wick P.  and  Borges O. (2020). Hazard Assessment of Polymeric Nanobiomaterials for Drug Delivery: What Can We Learn From Literature So Far, Front. Bioeng. Biotechnol. pdf

Marques C. , Som C. , Schmutz M. , Borges O. and Borchard  G. (2020). How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept, Front. Bioeng. Biotechnol. pdf

 

 

 


Contact

Claudia Som

 

Technology & Society Laboratory

Lerchenfeldstrasse 5

CH-9014 St. Gallen