Our activities are centered around

1. a better understanding of disease etiology by employing particle-based model systems (Disease Etiology),
2. the development of particle-based biosensors (Diagnostics), and

3. the design of particles for targeted drug delivery (Drug Delivery).

The design specs for our particle-based solutions are given by the clinical problem to be solved. We design our particle-based solutions bottom up in close exchange with our clinical collaborators as well as academic partner institutions around the world. We have expertise in particle synthesis and functionalization, characterization and imaging of particle-based systems, as well as translational nanomedicine.

We acknowledge financial support from the Swiss National Science Foundation, the Personalized Health and Related Technologies (PHRT) Initiative of the ETH Domain, the Swiss Heart Foundation, Krebsliga, the Novartis Foundation for Biomedical Research, the Novartis FreeNovation Program, the Bangerter Rhyner Foundation, the Helmut Horten Foundation, the Olga Mayenfisch Foundation, the OPO Foundation and others.

Research Activities

Theranostic Magnetic Blood Purification

We develop a theranostic nanoparticle-based approach that allows capturing of pathogenic compounds from blood and rapid identification of the pathogen enabling doctors to then start appropriate treatment in due time.

We have close collaborations with Marco Lattuada (AMI/University of Fribourg) and Gerald Pier (Harvard University). This project is supported by the Novartis Foundation for medical-biological research.

 

 

Tissue Glue for Integrative Wound Care and Regenerative Medicine (NANOGLUE)

We engineer fully resorbable bioactive nanoparticle-based tissue glues that allow surgeons to achieve rapid hemostasis and wound closing and optimally support the natural healing process by releasing bioactive compounds.

This work is collaboration with the Cantonal Hospital (Oncology Department) and the Inselspital Bern (Plastic Surgery Department). We acknowledge support from the Swiss National Science Foundation, the Bangerter Rhyner Foundation, the Helmut Horten Foundation and the OPO Foundation!

 

nanoCalcification

We employ a combinatorial materials science approach that enables us for the first time to integrate structural information of the mineral with biochemical information. In this way, we achieve a fresh view on complex biomineralization mechanisms involved in pathological calcification and gain new insights into the underlying processes that can then be leveraged to develop novel curative strategies.

These activities are kindly supported by the Swiss Heart Foundation, the Swiss National Science Foundation and the ETH Domain SFA Personalized Health and Related Technologies (PHRT) Program and are carried out in close collaboration with the Mineralomics group chaired by Dr. S. Bertazzo, University College London, UK, the Cantonal Hospital St. Gallen KSSG (Prof. Thürlimann / PD Dr. Knauer, Prof. Hornung and Prof. Wildermuth), and the ARTORG/Inselspital Bern (Prof. Obrist and Prof. Carrel).

 

Multiscale Correlative BioImaging (eLUM)

We develop methods that allow us to integrate the major imaging methods used in biology, from the micro to the macro scale. With this approach we are able to correlate data from the key imaging methods used by today’s biologists and biochemists thereby providing groundwork to significantly advance the holistic understanding of both physiological and pathological processes by linking structural with functional information. Our activities include Correlative Cathodoluminescence Electron Microscopy (CCLEM), molecular labelling approaches and chemometric analyses of tissues by vibrational spectroscopy approaches. 

We acknowledge support from the European Union Seventh Framework Programm ESTEEM2 (imaging), the Novartis Freenovation Program (AI-assisted Spectral Pathology) the Olga Mayenfisch Foundation (Molecular Radiotherapy).

 

 

Particle Characterization Lab & Measurement Science

We host a particle characterization lab where we investigate colloidal stability of inorganic (metal and metal oxides) and organic particles (liposomes, polymersomes and exosomes) under a range of physiologically relevant conditions. We are part of the European Nanoparticle Characterization Lab project (EU-NCL).  In addition to characterizing colloidal suspensions, we develop tools for online monitoring of reactions on particle surfaces. Our particle characterization instruments (including a Nanoparticle Tracking Analysis Instrument with Fluorescence module and a Malvern Zeta sizer) are accessible to other users within and outside of Empa.

 

 

Team

 

 

Prof. Dr Inge K. Herrmann, Assistant Professor (ETH, D-MAVT) and Group Leader

, +41 (0)58 765 71 53

@IngeKHerrmann

Alma Mater: ETH Zurich

Keywords: Chemical Engineering, Particle Synthesis and Functionalization, Bioimaging, Translational Research

 

Dr Matthias Rösslein, Senior Scientist

Alma Mater: University of Basel

Keywords: Physical Chemistry, Particle Characterization, Measurement Science, Bioinformatics, Next Generation Sequencing

 

Dr Alexander Gogos, Research Specialist

Alma Mater: ETH Zurich, RWTH Aachen

alexander.gogos@empa.ch

Keywords: Analytical Chemistry, Elemental Analysis (ICP-OES/MS), Field-Flow-Fractionation, Analytical Electron Microscopy

 

Dr Fabian Starsich, Postdoctoral Reserach Associate

fabian.starsich@empa.ch

Alma Mater: ETH Zurich

Keywords: Nanoparticle Synthesis, Engineering, Biomedical Applications

 

Dr Elena Tsolaki, Postdoctoral Research Associate at Empa/ETHZ

elena.tsolaki@empa.ch

Alma Mater: University College London

Keywords: Mineralomics, Microscopy, Calcification

 

Dr Alice Balfourier, Postdoctoral Research Associate at Empa/ETHZ

alice. balfourier@empa.ch

Alma Mater: University of Paris

Keywords: Advanced Microcopy, Biotransformation, Inorganic Nanomaterials, Omics

 

Dr Thomas Rduch, MD, Clinical Research Fellow

thomas.rduch@empa.ch

Clinical Research Fellow and Attending Physician at KSSG

 

Dr Tino Matter, ETH Pioneer Fellow (Anavo)

tinomavt.ethz.ch

Alma Mater: University of Basel (MSc), ETH Zurich (PhD)

Key words: Nanotechnology, Physics, Programming

 

Dr Alexandre Anthis, ETH Pioneer Fellow (Veltist)

Alma Mater: University of Geneva (MSc), ETH Zurich (PhD)

Key words: (Polymer) Chemistry, ATRP,  Analytics, Entrepreneurship

 

Mr. Lukas Gerken, PhD student since 04/2018 

Alma Mater: University of Cologne and TU Vienna

Key words: Physics, Nanoparticle Synthesis, Optical Properties of Nanomaterials

 

Mr. Subas Scheibler, PhD student (jointly with 203) since 04/2019

subas.scheibler@empa.ch

Alma Mater: University of Zurich

Key words: Physics, Thin Film Fab, New Materials for Healthcare 

 

Ms. Anna L. Neuer, PhD student since 05/2019

annalena.neuer@empa.ch

Alma Mater: University of Constance, D

Keywords: Cell Culture, Metal Organic Frameworks, Microscopy

 

Mr. Oscar Cipolato, PhD student since 10/20

Alma Mater: Msc Physics (University of Padova)

Keywords: Physics, Simulations, Coding

 

Ms. Judith Ng,  PhD student since 10/20

Alma Mater: Msc Biomedical Engineering (University of Toronto)

Keywords: Cell culture, Bacteria culture, Tissue engineering, Adhesion

 

Ms. Monika Zimmermann, PhD student since 02/21

MSc Physics (ETHZ) 

Keywords: Physics, Simulations, Radiotherapy, Nanoparticles

 

Mr. Erik Mayr, PhD Student since 05/21

MSc Physiscs (University of Basel)

Keywords: Magnetism, Nanoparticles, Sputtering, Thin Film Phyiscis

Mr. Benjamin Suter, PhD student since 07/21

MSc Physics (ETHZ)

Keywords: AI, Computer Vision, Sensing

Alumni

Postdocs

Dr Jian Hao-Li, Postdoctoral Reserach Associate, Novartis FreeNovation

Alma Mater: University of Cambridge, UK

Keywords: Theoretical Physics, Condensed Matter Physics, Quantum Mechanics, Deep Learning, Machine Learning, Data Analysis

 

Dr Kerda Keevend, Postdoctoral Research Associate at ETH Zurich (D-MAVT)

Alma Mater: ETH Zurich

Keywords: Inorganic Nanocrystal Synthesis, Correlative Cathodoluminescence Electron Microscopy

 

Doctoral students

Dr Kerda Keevend, PhD student  04/2016 - 12/2019 (defended 7/11/19)

Dr Tino Matter, PhD student, 05/2017-09/2020 (defended 18/09/2020)

Dr Alexandre Anthis, PhD student, 10/2017-05/2021 (defended 06/05/2021)

 

BSc and MSc students

Mr. Alexander Jessernig, MSc student, D-ITET, MSc thesis, 2021

Ms. Maren Gerdes, BSc student, Karolinska, 2021

Mr. Juri Nowak, BSc student, ETHZ, D-MAVT, BSc thesis, 2020

Mr. Raphael Langenegger, ETHZ, D-MAVT, BSc thesis, 2020

Mr. Jerome Schlatter, ETHZ, D-MAVT, BSc thesis, 2020

Mr. Eric Rüttimann, MSc student Chemistry, ETHZ, MSc thesis, 2020 

Ms. Leonida Maliqi, MSc student, 2019, University of Geneva

Ms. Lea Pompizzi, MSc student Chemistry, 2019, ETH Zurich

Mr. Xueqian Hu, MSc student, 2019, MSc student, University of Darmstadt, Germany

Ms. Meagan Doppegieter 2018-2019, MSc student, University of Amsterdam (UvA), NL

Mr. Henry Korhonen, 2018, ETH Zurich, D-MATL, BSc student

Ms. Apolline Anthis, 2018, University of Ioannina (GR), MSc student

Ms. Lea Furer, 2018, ETH Zurich, D-ITET, MSc student

Mr. Roman Krummenacher, 2018, ETH Zurich, D-MAVT, BSc student

Ms. Egle Truska, 2017-2018, University of Tallinn (E), MSc student

Mr. Dimitri Hürlimann, 2017-2018, University of Basel, MSc student

Mrs. Behnaz Ghaemi, 2017, University of Tehran, Visiting PhD student

Mr. Louis Didierlaurent, 2016-2017, Ecole Superieure de Chimie Physique Electronique de Lyon, MSc student

Mr. Nino Demarmels, 2016-2017, ETH Zurich, MSc student

Mr. Samuel Staubli, 2016, ETH Zurich, Project student

Mr. Marco Galli, 2016, University of Milan, Visiting PhD student

Ms. Anna L. Neuer, 2016, University of Konstanz, BSc student

Mr. Eric Rüttimann, MSc student Chemistry 

Selected Publications

2021

Matter, Martin T., Maliqi, Leonida, Keevend, Kerda, Guimond, Stefanie, Ng, Judith, Armagan, Efe, Rottmar, Markus and Inge Herrmann*. One-​Step Synthesis of Versatile Antimicrobial Nano-​Architected Implant Coatings for Hard and Soft Tissue Healing. ACS Applied Materials & Interfaces 13.28 (2021): 33300-​33310.

Herrmann, Inge K.*, Wood, Matthew J.A. and Gregor Fuhrmann. Extracellular vesicles as a next-​generation drug delivery platform. Nature Nanotechnology 16 (2021): 748-​759.

Geissel Felix, Platania, Varvara, Gogos, Alexander, Herrmann, Inge, Belibasakis, Georgios, Chatzinikolaidou, Maria,  Sotiriou, Georgios, Journal of Colloids and Interfaces, accepted, 2021.

Lese, Ioana, Tsai, Catherine, Matter, Martin T., Wüthrich, Tsering, Scheer, Helene S., Taddeo, Adriano, Constantinescu, Mihai A., Herrmann, Inge and Radu Olariu. Mixed Metal Oxide Nanoparticle Formulations for the Treatment of Seroma. ACS Biomaterials Science & Engineering 7.6 (2021): 2676-​2686.

Gerken, Lukas R.H., Neuer, Anna L., Gschwend, Pascal, Keevend, Kerda, Gogos, Alexander, Anthis, Alexandre H.C., Aengenheister, Leonie, Pratsinis, Sotiris E., Plasswilm, Ludwig and Inge Herrmann*. Scalable Synthesis of Ultrasmall Metal Oxide Radio-​Enhancers Outperforming Gold. Chemistry of Materials 33.9 (2021): 3098-​3112.

Matter, Martin T., Doppegieter, Meagan, Gogos, Alexander, Keevend, Kerda, Ren, Qun and Inge Herrmann*. Inorganic nanohybrids combat antibiotic-​resistant bacteria hiding within human macrophages. Nanoscale 13.17 (2021): 8224-​8234. **Emerging Investigator Collection

Anthis, Alexandre H. C., Hu, Xueqian, Matter, Martin T., Neuer, Anna L., Wei, Kongchang, Schlegel, Andrea A., Starsich, Fabian H. L. and Inge K. Herrmann*. Chemically Stable, Strongly Adhesive Sealant Patch for Intestinal Anastomotic Leakage Prevention. Advanced Functional Materials (2021): 2007099.

Gschwend, Pascal, Keevend, Kerda, Aellen, Marianne, Gogos, Alexander, Krumeich, Frank, Herrmann, Inge K. and Sotiris E. Pratsinis. Bi2O3 boosts brightness, biocompatibility and stability of Mn-​doped Ba3(VO4)2 as NIR-​II contrast agent. Journal of Materials Chemistry B (2021).

2020

Gschwend, Pascal, Hintze, Justin M., Herrmann, Inge K., Pratsinis, Sotiris E. and Fabian H. L. Starsich. Precision in Thermal Therapy: Clinical Requirements and Solutions from Nanotechnology. Advanced Therapeutics 4.2 (2021): 2000193.

K. Keevend, R. Krummenacher, E. Truska, L.H.R Gerken, A. Gogos, M. Stiefel, I.K. Herrmann*, Correlative Cathodoluminescence Electron Microscopy: Immunolabelling using Rare-Earth Element doped Nanoparticles, Small, accepted, 2020

M.T. Matter, S. Probst, S. Laeuchli, I.K. Herrmann*, Uniting Drug and Delivery: Metal Oxide Hybrid Nanotherapeutics for Skin Wound Care, Pharmaceutics, accepted (2020). Invited article - Special Issue on Hybrid Multifunctional Drug Delivery Systems

K. Keevend, T. Coenen, I.K. Herrmann*, Correlative Cathodoluminescence Electron Microscopy Bioimaging: towards Single Protein Labelling with Ultrastructural Context, Nanoscale (2020).

A.L. Neuer, L.H.R. Gerken, K. Keevend, A. Gogos, I.K. Herrmann*, Uptake, Distribution and Radio-enhancement Effects of Gold Nanoparticles in Tumor Microtissues, Nanoscale Adv. (2020).

M.T. Matter, J.H. Li, I. Lese, C. Schreiner, L. Bernard, O. Scholder, J. Hubeli, K. Keevend, E. Tsolaki, E. Bertero, S. Bertazzo, R. Zboray, R. Olariu, M. Constantinescu, R. Figi, I.K. Herrmann*, Multi-scale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and Biotransformation, Advanced Science, accepted (2020).

P.M. Gschwend, D. Niedbalka, L.R.H. Gerken, I.K. Herrmann, S.E. Pratsinis, Simultaneous Nanothermometry and Deep-tissue Imaging, Advanced Science, DOI: 10.1002/advs.202000370 (2020).

F. Iacoviello, E. Moeendarbary, A.C. Kirby, Y. Javanmardi, E. Tsolaki, M. Shabanli, A.C. Sharp, M.J. Hayes, K. Keevend, D.J. Brett, J.-H. Li, P.R. Shearing, A. Olivo, I.K. Herrmann, S.E. Evans, M. Moazen, S. Bertazzo, The multiscale hierarchical structure of heloderma suspectum osteoderms and their mechanical properties, Acta Biomaterialia, accepted, 2020.

Pre-prints

E. Tsolaki, W. Doran, L. Magnani, A. Olivo, I.K. Herrmann, S. Bertazzo, Invasive breast tumors are characterized by the presence of crystalline nanoparticles, biorxiv, 2020.

E. Tsolaki, L. Didierlaurent, E. Müller, M. Rottmar, N. Latif, A.H. Chester, I.K. Herrmann, S. Bertazzo, Electron microscopy characterization of minerals formed in vitro by human bone cells and vascular smooth muscle cells, bioRXiv, https://doi.org/10.1101/661785.

2019

K.C. Wei, B. Senturk, M.T. Matter, X. Wu, I.K. Herrmann, M. Rottmar, C. Toncelli, Mussel-inspired injectable hydrogel adhesive formed under mild conditions features near-native tissue properties, ACS Applied Materials and Interfaces, accepted. 

A.H.C. Anthis, M.T. Matter, K. Keevend, L.H.R. Gerken, S. Scheibler, S. Doswald, A. Gogos, I.K. Herrmann*, Tailoring the Colloidal Stability, Magnetic Separability and Cytocompatibility of High-Capacity Magnetic Anion Exchangers, ACS Applied Materials and Interfaces, accepted, 2019.

A.H.C. Anthis, E. Tsolaki, L. Didierlaurent, S. Staubli, R. Zboray, A. Neels, D. Dietrich, P. Manser, L.M. Desbiolles, S. Leschka, S. Wildermuth, S. Lehner, P. Chavatte-Palmer, W. Jochum, P. Wick, A, Dommann, T. Bürki-Turnherr, T. Fischer, R. Hornung, S. Bertazzo, I.K. Herrmann*, Nano-analytical Characterization of Endogenous Minerals in Healthy Placental Tissue: Mineral Distribution, Composition and Ultrastructure, Analyst, 2019, 144, 6850-6857. * featured on the front cover

K. Keevend, L. Puust, K. Kurvits, L.H.R. Gerken, F.H.L Starsich, J.H. Li, M.T. Matter, A. Spyrogianni, G. Sotiriou, M. Stiefel, I.K. Herrmann*, Ultra-Bright and Stable Luminescent Labels for Correlative Cathodoluminescence Electron Microscopy (CCLEM) Bioimaging, Nano Letters, 2019.

F.H.L. Starsich, I.K. Herrmann, S.E. Pratsinis, Nanoparticles for Biomedicine: Coagulation during Synthesis and Applications, Annual Review of Chemical and Biomolecular Engineering, accepted, 2019.

2018

M.T. Matter, L. Furer, F.H.L. Starsich, G. Fortunato, S.E. Pratsinis, I.K. Herrmann*, Engineering the Bioactivity of Flame-made Ceria and Ceria/Bioglass Hybrid Nanoparticles, ACS Applied Materials and Interfaces, accepted, 2018. *senior and corresponding author

L. Gerken, K. Keevend, Y. Zhang, F.H.L. Starsich, C. Eberhardt, G. Panzarasa, M.T. Matter, A. Wichser, A. Boss, A. Neels, I.K. Herrmann*, Lanthanide-doped Hafnia Nanoparticles for Multimodal Theranostics, ACS Applied Materials and Interfaces, accepted, 2018. *senior and corresponding author

I. Lese, D.A. Graf, C. Tsai, A. Taddeo, M.T. Matter, M. Constantinescu, I.K. Herrmann, R. Olariu, Bioactive nanoparticle-based formulations increase  survival area of perforator flaps in a rat model, Plos One, accepted, 2018.

F.H.L. Starsich, C. Eberhard, K. Keevend, A. Boss, A.M. Hirt, I.K. Herrmann, S.E. Pratsinis, Reduced magnetic coupling in ultra-small iron oxide T1 contrast agents, ACS Applied Bio Materials, accepted, 2018.

E. Bertero, M. Hasegawa, S. Staubli, E. Pellicer, I.K. Herrmann, J. Sort,  J. Michler, L. Philippe,  Electrodeposition of amorphous Fe-Cr-Ni stainless steel alloy with high corrosion resistance, low cytotoxicity and soft magnetic properties, Surface and Coatings Technology, accepted, 2018.

K. Keevend, G. Panzarasa, F.H.L Starsich, M. Zeltner, A. Spyrogianni, E. Tsolaki, G. Fortunato, S.E. Pratsinis, S. Bertazzo, I.K. Herrmann*, Facile meltPEGylation of Flame-made Luminescent Tb3+-dopedYttrium Oxide Particles: Hemocompatibility, Cellular Uptake and Comparison to Silica, Chemical Communications, accepted, 2018, 54, 2914-2917. *senior and corresponding author

A. Spyrogianni, P. Tiefenboeck, F. Starsich, K. Keevend, F. Krumeich, I.K. Herrmann, J.C. Leroux, G. Sotiriou, Near-UV activated, photostable nanophosphors for in vitro dosimetry and dynamic bioimaging, AIChE Journal, accepted, 2018.

2017

N. Bohmer, N. Demarmels, E. Tsolaki, L. Gerken, K. Keevend, S. Bertazzo, M. Lattuada, I.K. Herrmann*, Removal of Cells from Body Fluids by Magnetic Separation in Batch and Continuous Mode: Influence of Bead Size, Concentration, and Contact Time, ACS Applied Material and Interfaces. 2017. doi: 10.1021/acsami.7b10140. *senior and corresponding author

A. Spyrogianni, I.K. Herrmann, K. Keevend, S.E. Pratsinis, K. Wegner, The silanol content and in vitro cytolytic activity of flame-made silica, Journal of Colloid and Interface Science. 507:95-106 (2017).

M.T. Matter, F. Starsich, M. Galli, M. Hilber, A.A. Schlegel, S. Bertazzo, S.E. Pratsinis, I.K. Herrmann*, Developing a tissue glue by engineering the adhesive and hemostatic properties of metal oxide nanoparticles, Nanoscale, 9(24):8418-8426 (2017). *senior and corresponding author. Altmetric Top 5%!

G. Fuhrmann, A.L. Neuer, I.K. Herrmann, Extracellular vesicles - a promising avenue for the detection and treatment of infectious diseases, European Journal of Pharmaceutics and Biopharmaceutics, 10.1016/j.ejpb.2017.04.005. (2017). (Invited).

K. Keevend, M. Stiefel, A.L. Neuer, M.T. Matter, A. Neels, S. Bertazzo, I.K. Herrmann*, Tb3+-doped LaF3 nanocrystals for correlative cathodoluminescence electron microscopy imaging with nanometric resolution in focus ion beam-sectioned biological samples, Nanoscale, 30;9(13):4383-4387 (2017). *senior and corresponding author ** featured on the Back Cover of Nanoscale. Altmetric Top 25%!

M. Rösslein, N. Liptrott, A. Owen, P. Boisseau, P. Wick, I.K. Herrmann*, Sound Understanding of Environmental, Health and Safety, Clinical, and Market Aspects is Imperative to Clinical Translation of Nanomedicines, Nanotoxicology, 11(2):147-149 (2017). *senior and corresponding author

2016

M. Lattuada, Q. Ren, F. Zuber, M. Galli, N. Bohmer, M.T. Matter, A. Wichser, S. Bertazzo, G.B. Pier, I.K. Herrmann*, Theranostic Body Fluid Cleansing: Rationally designed magnetic particles enable capturing and detection of bacterial pathogens, Journal of Materials Chemistry B, 4, 7080—7086 (2016) *senior and corresponding author ** featured on the Back Cover of J. Mater. Chem. B, 2016, 4, 7169-7170. *** featured in international newspapers and radio shows, including the Omega Watches Lifetime Magazine, Nanowerk, Deutschlandfunk, etc. Altmetric Top 5%!

Q. Flamant, C. Caravaca, S. Meille, L. Grémillard, J. Chevalier, K. Biotteau, M. Kuntz, R. Chandrawati, I.K. Herrmann, C.D. Spicer, M.M. Stevens, M. Anglada, Selective etching of injection molded zirconia toughened alumina: towards osseointegrated and antibacterial ceramic implants, Acta Biomaterialia, 46, 308-322 (2016).

A. Spyrogianni, I. K. Herrmann, M. S. Lucas, J-C. Leroux, G. A. Sotiriou. Quantitative analysis of the deposited nanoparticle dose on cell cultures by optical absorption spectroscopy, Nanomedicine, 11(19):2483-96 (2016).

I.K. Herrmann*, B. Beck-Schimmer, C.M. Schumacher, S. Gschwind, A. Kaech, U. Ziegler, P.A. Clavien, D. Günther, W.J. Stark, R. Graf, A.A. Schlegel, In vivo risk evaluation of carbon-coated iron carbide nanoparticles based on short and long-term exposure scenarios, Nanomedicine, 11(7):783-96, (2016). *corresponding author

I.K. Herrmann* and M. Rösslein, Personalized Medicine: The enabling Role of Nanotechnology, Nanomedicine, 11(1):1-3 (2016). *corresponding author. *one of the most accessed articles of 2016 across all Future Medicine journals (Editorial)

2015

M. Jacobson, B. Roth Z'graggen, S. Graber, C.M. Schumacher, W.J. Stark, C. Dumrese, J. Mateos, C. Aemisegger, U. Ziegler, M. Urner, I.K. Herrmann*, B. Beck-Schimmer*, Uptake of Ferromagnetic Carbon-encapsulated Metal Nanoparticles in Endothelial Cells: Influence of Shear Stress and Endothelial Activation, Nanomedicine, 10(24):3537-46 (2015). **co-senior author

C.S. Almeida, I.K. Herrmann, P. Howes, M.M. Stevens, Tailoring cellular uptake of conjugated polymer nanoparticles using modular amphiphilic peptide capping ligands, Chemistry of Materials, 27(19), 6879–6889, (2015).

I.K. Herrmann*, S. Bertazzo, D.J.P. O’Callaghan, A. Schlegel, C. Kallepitis, D. Antcliffe, A.C. Gordon, M.M. Stevens*, Differentiating Sepsis from Non-Infectious Systemic Inflammation based on Microvesicle-Bacteria Aggregation, Nanoscale, 7(32):13511-20 (2015). *corresponding author

G. Fuhrmann, I.K. Herrmann, M.M. Stevens, Cell-derived vesicles for drug therapy and diagnostics: opportunities and challenges, Nano Today, 10 (3), 397–409 (2015). (Invited Review)

I.K. Herrmann, A. Schlegel, R. Graf, W.J. Stark, B. Beck-Schimmer, Magnetic Separation-Based Blood Purification: A Promising New Approach for the Removal of Disease-causing Compounds, Journal of Nanobiotechnology, 13:49 (2015). (Perspective).

M. Urner, M. Schläpfer, I.K. Herrmann, M. Hasler, R.C. Schimmer, C. Booy, B. Roth-Z’graggen, H. Rehrauer, F. Aigner, R.D. Minshall, W.J. Stark, B. Beck-Schimmer, Insight into the beneficial immunomodulatory mechanism of the sevoflurane metabolite hexafluoro-2-propanol in a rat model of endotoxemia, Clinical and Experimental Immunology, 181(3):468-479 (2015).

I.K. Herrmann*, How Nanotechnology-enabled concepts could contribute to the prevention, diagnosis and therapy of bacterial infections, Critical Care, 19, 239-241, 2015. *corresponding author. (Viewpoint article) *highly-accessed

Before 2015

L. Bircher, O.M. Theusinger, S. Locher, P. Eugster, B. Roth-Z’graggen, C.M. Schumacher, J.-D. Studt, W.J. Stark, B. Beck-Schimmer, I.K. Herrmann*, Characterization of Carbon-Coated Magnetic Nanoparticles using Clinical Blood Coagulation Assays: Effect of PEG-Functionalization and Comparison to Silica Nanoparticles, Journal of Materials Chemistry B, 2, 3753-58 (2014). *corresponding author.

R. Fuhrer, S. Hofmann, N. Hild, J.R. Vetsch, I.K. Herrmann, R.N. Grass, W.J. Stark, Pressureless Mechanical Induction of Stem Cell Differentiation is Dose and Frequency Dependent, PLoS One, 8(11), e81362 (2013).

I.K. Herrmann*, A. Schlegel, R. Graf, C.M. Schumacher, N. Senn, S. Gschwind, A.M. Hirt, D. Günther, P.-A. Clavien,  W.J. Stark, B. Beck-Schimmer, Nanomagnet-based removal of lead and digoxin from living rats, Nanoscale, 5(18), 8718-23 (2013). *corresponding author. Featured in RSC Chemistry World (most read article in July 2013), RSC blog, Materials360online and the Swiss Innovation Report issued by the Swiss Government (SER).

I.K. Herrmann, M. Castellon, D.E. Schwartz, M. Hasler, M. Urner, G. Hu, R.D. Minshall, B. Beck-Schimmer,  Intravenous Hexafluoroisopropanol Application improves Outcome in Murine Septic Peritonitis, PLoS One,  8(8), e72057 (2013).

I.K. Herrmann, M. Castellon, D.E. Schwartz, M. Hasler, M. Urner, G. Hu, R.D. Minshall, B. Beck-Schimmer,  Volatile Anesthetics Improve Survival after Cecal Ligation and Puncture, Anesthesiology, 119(4), 901-6 (2013). Featured in editorial views.

C.M. Schumacher, I.K. Herrmann, S.B. Bubenhofer, S. Gschwind, A.M. Hirt, B. Beck-Schimmer, D. Günther and W.J. Stark, Quantitative Recovery of Magnetic Nanoparticles from Flowing Blood: Trace Analysis and the Role of Magnetization, Advanced Functional Materials, 23(39), 4888-96 (2013). Featured on cover of the Advanced Functional Materials, 23(39), 1, 2013. Featured in Materials Views.

I.K. Herrmann, M. Urner, S. Graf, C.M. Schumacher, B. Roth-Z’Graggen, M. Hasler, W.J. Stark, B. Beck-Schimmer,  Endotoxin Removal by Magnetic Separation-based Blood Purification, Advanced Healthcare Materials, 2(6), 829-35 (2013). Featured as frontispiece image in Advanced Healthcare Materials, 2(6), 828 (2013).

M. Urner, I.K. Herrmann, C. Booy , B. Roth-Z’Graggen, M. Maggiorini, B. Beck-Schimmer, Effect of Hypoxia and Dexamethasone on Inflammation and Ion Channel Function in Lung Cells, Clinical and Experimental Immunology, 169(2), 119-28 (2012). 

M. Urner, I.K. Herrmann, F. Buddeberg, C. Schuppli , B. Roth-Z’Graggen, M. Hasler, U. Schanz, M. Mehr, D.R. Spahn, B. Beck-Schimmer, Effects of Blood Products on Inflammatory Response in Endothelial Cells in vitro, PLoS One, 7(3), e33403 (2012).

I.K. Herrmann, M. Urner, M. Hasler, B. Roth-Z’Graggen, C. Aemisegger, W. Baulig, E.K. Athanassiou, S. Regenass, W.J. Stark, B. Beck-Schimmer, Iron Core/Shell Nanoparticles as Magnetic Drug Carriers: Possible Interactions with the Vascular Compartment, Nanomedicine, 6, 1199-1213 (2011).

M. Urner, L.K. Limbach, I.K. Herrmann, W.J. Stark, B. Beck-Schimmer, Fluorinated carbon groups mediate the immunomodulatory effects of volatile anesthetics, American Journal of Respiratory Cell and Molecular Biology, 45(3), 617-24 (2011).

I.K. Herrmann, R.E. Bernabei, M. Urner, R.N. Grass, B. Beck-Schimmer, W.J. Stark, Device for Continuous Extracorporeal Blood Purification using Target-specific Metal Nanomagnets, Nephrology Dialysis Transplantation, 26 (9), 2948-2954 (2011). Featured in MIT Technology Report Review, various international newspapers and TV shows (BR, ARD (Germany), arte (France), SF2 (Switzerland).

R. Fuhrer, I.K. Herrmann, E.K. Athanassiou, W.J. Stark, Immobilized  β-Cyclodextrin on carbon coated cobalt nanomagnets: reversible organic contaminant adsorption and enrichment from water, Langmuir, 27(5), 1924-9 (2011).

I.K. Herrmann, M. Urner, F.M. Koehler, M. Hasler, B. Roth Z’Graggen, R.N. Grass, U. Ziegler, B. Beck-Schimmer, W.J. Stark, Blood Purification using Core/Shell Nanomagnets, Small, 6 (13) 1388-1392 (2010). Featured in Nature Nanotechnology, 5, 628 (2010).

I.K. Herrmann, R.N. Grass, W.J. Stark, High-strength metal nanomagnets for diagnostics and medicine: carbon shells allow long-term stability and reliable linker chemistry, Nanomedicine, 4(7):787-98 (2009).

I.K. Herrmann, R.N. Grass, D. Mazunin, W.J. Stark, Synthesis and Covalent Surface Functionalization of Nonoxidic Iron Core-Shell Nanomagnets, Chemistry of Materials, 21(14), 3275-81 (2009).