An engineered, sutureless, self-adhesive corneal transplant to treat corneal defects

An engineered corneal transplant is being developed to address the global shortage of donor corneas and overcome the limitations of current surgical treatments. This approach uses a double network hydrogel (DNH) to create a sutureless alternative for treating corneal defects. The DNH is composed of two main components to mimic the natural structure of the cornea and to provide enhanced stability and adhesive properties. The hydrogel can be used as a simple acellular scaffold or as a tissue engineering graft with encapsulated corneal cells. Using 3D printing technology, patient-specific shapes can be created based on scans of a patient’s eye, ensuring a precise fit. The printing process also helps to obtain strucutral features of the cornea in order to maintain the implant's transparency and strength. This approach offers a sustainable, accessible and efficient solution that reduces the risks of immune rejection, infection and other complications associated with traditional corneal transplants.

 


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Support: Undisclosed Foundation