Cells at Surfaces
The cells at surfaces group aims to understand the mechanisms of how human cells and tissues interact with materials/material surfaces and to use this knowledge for the development of novel materials for Healthcare applications.
Using novel advanced in vitro models that more closely mimic the in vivo situation; we study the cellular events governing integration or non-integration of materials into host tissue as well as cellular processes involved in wound healing. We are also interested in how drug-releasing materials can be used to steer the tissue response.
Improving wound healing
Our goal is to understand the occurrence of and mechanisms involved in impaired wound healing, tissue scarring as well as fibrosis induced by the implantation of biomaterials for the development of material-based treatment strategies. For this, we develop new in vitro models including co-cultures and 3D-cultures and use analytical tools including Microarray-technology, ELISAs, SEM or 2-photon microscopy.
Steering integration and non-integration of materials
Our aim is to understand how such material properties influence different stages of the tissue response to implants and to develop novel materials and material surfaces to either achieve or to avoid tissue integration.
Our tool box
We study cell-material interactions as well as the early events of blood-material interaction and its influence on human cell response by developing tissue-specific in vitro models mainly focusing on bone, skin and soft tissue. Ultimately, we evaluate the predictive power of our models via correlation with in vivo results and clinical data. For this, we use state of the art techniques including gene- and protein expression analysis, siRNA or fluorescence microscopy.