A Sensor for Emerging Bio-threats

The ongoing outbreak of the novel coronavirus disease (COVID-19) has spread globally and poses a threat to public health in more than 200 countries. Reliable laboratory diagnosis of the disease has been one of the foremost priorities for promoting public health interventions.

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A Thermo-Plasmonic Sensor for Viral Diagnosis

The routinely used reverse transcription polymerase chain reaction (RT-PCR) is currently the reference method for COVID-19 diagnosis. However, it also reported a number of false-positive or-negative cases, especially in the early stages of the novel virus outbreak. In this work, a dual-functional plasmonic biosensor combining the plasmonic photothermal (PPT) effect and localized surface plasmon resonance (LSPR) sensing transduction provides an alternative and promising solution for the clinical COVID-19 diagnosis. The two-dimensional gold nanoislands (AuNIs) functionalized with complementary DNA receptors can perform a sensitive detection of the selected sequences from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through nucleic acid hybridization.

For better sensing performance, the thermoplasmonic heat is generated on the same AuNIs chip when illuminated at their plasmonic resonance frequency. The localized PPT heat is capable to elevate the in situ hybridization temperature and facilitate the accurate discrimination of two similar gene sequences. Our dual-functional LSPR biosensor exhibits a high sensitivity toward the selected SARS-CoV-2 sequences with a lower detection limit down to the concentration of 0.22 pM and allows precise detection of the specific target in a multigene mixture. This study gains insight into the thermoplasmonic enhancement and its applicability in the nucleic acid tests and viral disease diagnosis.

Jing Wang Explains this Breakthrough

From Falling Walls 2020

Prof. Dr. Jing Wang

Prof. Dr. Jing Wang
PI Nanoparticle Analysis

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Qiu, G.; Gai, Z.; Saleh, L.; Tang, J.; Gui, T.; Kullak-Ublick, G. A.; Wang, J. Thermoplasmonic-assisted cyclic cleavage amplification for self-validating plasmonic detection of SARS-CoV-2. ACS Nano 2021, 15 (4), 7536-7546. https://doi.org/10.1021/acsnano.1c00957
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Schmitt, J.; Wang, J. Quantitative modeling of the impact of facemasks and associated leakage on the airborne transmission of SARS-CoV-2. Sci. Rep. 2021, 11 (1), 19403 (15 pp.). https://doi.org/10.1038/s41598-021-98895-9
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Zhang, X.; Wang, J. Dose-response relation deduced for coronaviruses from coronavirus disease 2019, severe acute respiratory syndrome, and Middle East respiratory syndrome: meta-analysis results and its application for infection risk assessment of aerosol transmission. Clin. Infect. Dis. 2021, 73 (1), e241-e245. https://doi.org/10.1093/cid/ciaa1675
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